InterPro domain: IPR002466

Editase ( 3.5 ) are enzymes that alter mRNA by catalyzing thesite-selective deamination of adenosine residue into inosine residue.The editase domain contains the active site and binds three Zn atoms [ 1 ].

Several editases share a common global arrangement of domains, from N to C terminus: two'double-stranded RNA-specific adenosine deaminase' (DRADA) repeat domains, followed bythree 'double-stranded RNA binding' (DsRBD) domains, followed bythe editase domain. Other editases have a simplified domains structure with noDRADA_REP and possibly fewer DSRBD domains. Editase that deaminate cytidine are not detected by this signature.

1. Mammalian RNA-dependent deaminases and edited mRNAs. Curr. Opin. Cell Biol. 9, 343-9