InterPro domain: IPR002288

General Information

  • Identifier IPR002288
  • Description DNA gyrase B subunit, C-terminal

Abstract

This entry represents the C-terminal of the DNA gyrase B. The N terminus of eukaryotic and prokaryotic DNA topoisomerase II are similar, but they have a different C terminus. The N-terminal of the DNA gyrase B protein is thought to catalyse the ATP-dependent super-coiling of DNA. The C-terminal end supports the complexation with the DNA gyrase A protein and the ATP-independent relaxation. This entry also contains Topoisomerase IV, which is a bacterial enzyme that is closely related to DNA gyrase [ 1 , 2 ].


1. The mechanisms of DNA topoisomerases. Trends Biochem. Sci. 20, 156-60
2. Structure and mechanism of DNA topoisomerase II. Nature 379, 225-32

Species distribution

Gene table