InterPro domain: IPR002218
General Information
- Identifier IPR002218
- Description tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related
- Number of genes 139
- Gene duplication stats Loading...
- Associated GO terms GO:0050660 GO:0008033
Abstract
MnmG (also known as GidA) is a tRNA modification enzyme found in bacteria and mitochondria. Though its precise molecular function of these proteins is not known, it is involved in the 5-carboxymethylaminomethyl modification of the wobble uridine base in some tRNAs [ 1 , 2 ]. Sequence variations in the human mitochondrial protein may influence the severity of aminoglycoside-induced deafness [ 3 ].
This entry includes MnmG and related proteins, such as the methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase enzyme TrmFO.
1. Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J. Biol. Chem. 280, 1613-24
2. Translational misreading: a tRNA modification counteracts a +2 ribosomal frameshift. Genes Dev. 15, 2295-306
3. Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3. Mol. Genet. Metab. 83, 199-206