InterPro domain: IPR002123

This family is found in diverse acyltransferases involved in phospholipid biosynthesis [ 1 ]. This domain is found in tafazzins, phospholipid transacylases involved in the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation and whose defects cause of Barth syndrome; a severe inherited disorder which is often fatal in childhood and is characterised by cardiac and skeletal abnormalities [ 2 ]. Phospholipid/glycerol acyltransferase is not found in the viruses or the archaea and is under represented in the bacteria. Bacterial glycerol-phosphate acyltransferases are involved in membrane biogenesis since they use fatty acid chains to form the first membrane phospholipids [ 3 ].

1. Barth syndrome may be due to an acyltransferase deficiency. Curr. Biol. 7, R465-6
2. Tafazzin Mutation Affecting Cardiolipin Leads to Increased Mitochondrial Superoxide Anions and Mitophagy Inhibition in Barth Syndrome. Cells 9
3. Thematic review series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis. J. Lipid Res. 49, 1867-74