InterPro domain: IPR001950
General Information
- Identifier IPR001950
- Description SUI1 domain
- Number of genes 785
- Gene duplication stats Loading...
- Associated GO terms GO:0003743 GO:0006413
Abstract
In budding yeast (Saccharomyces cerevisiae), SUI1 is a translation initiationfactor that functions in concert with eIF-2 and the initiator tRNA-Met indirecting the ribosome to the proper start site of translation [ 1 ]. SUI1 is a protein of 108 residues. Close homologues of SUI1 have been found [ 2 ] in mammals, insects and plants. SUI1 is also evolutionary related to:
- Hypothetical proteins from bacteria such as Escherichia coli (yciH) or Haemophilus influenzae (HI1225).
- Hypothetical proteins from archaea such as Methanococcus jannaschii (MJ0463).
Two eukaryotic proteins also seem to contain a C-terminal SUI1-like domain.These are:
- Density-regulated protein (gene: DENR). This protein is found in mammals, insects, nematodes, plants and fungi.
- Ligatin (gene: LGTN). This protein is found in mammals and insects.
1. The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon. Mol. Cell. Biol. 12, 248-60
2. Expressed sequence tags identify a human isolog of the suil translation initiation factor. Biochem. Biophys. Res. Commun. 198, 288-91