InterPro domain: IPR001898

Integral membrane proteins that mediate the intake of a wide variety ofmolecules with the concomitant uptake of sodium ions (sodium symporters) canbe grouped, on the basis of sequence and functional similarities into a numberof distinct families. The SLC13 family consists mainly of dicarboxylate and sulfate transporters [ 1 , 2 ], and includes of the following proteins:

• Mammalian sodium/sulphate cotransporter [ 3 ].
• Mammalian renal sodium/dicarboxylate cotransporter [ 4 ], which transports succinate and citrate.
• Mammalian intestinal sodium/dicarboxylate cotransporter.
• Chlamydomonas reinhardtii putative sulphur deprivation response regulator SAC1 [ 5 ].

These transporters are proteins of from 430 to 620 amino acids which arehighly hydrophobic and which probably contain about 12 transmembrane regions.

1. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflugers Arch. 451, 597-605
2. SLC13 family of Na⁺-coupled di- and tri-carboxylate/sulfate transporters. Mol. Aspects Med. 34, 299-312
3. Expression cloning of rat renal Na+/SO4(2-) cotransport. Proc. Natl. Acad. Sci. U.S.A. 90, 8073-7
4. Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am. J. Physiol. 270, F642-8
5. Sac1, a putative regulator that is critical for survival of Chlamydomonas reinhardtii during sulfur deprivation. EMBO J. 15, 2150-9