InterPro domain: IPR001767

Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [ 1 ].

This entry represents the Hint module in the Hedgehog proteins. It does not include any Inteins, which also possess the Hint domain.

1. Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution. Cell 92, 1-4