InterPro domain: IPR001661

O-Glycosyl hydrolases ( 3.2.1. ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ 1 , 2 ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.

Glycoside hydrolase family 37 GH37 comprises enzymes with only one known activity; trehalase ( 3.2.1.28 ).

Trehalase is the enzyme responsible for the degradation of the disaccharide alpha,alpha-trehalose yielding two glucose subunits [ 3 ]. It is an enzyme found in a wide variety of organisms and whose sequence has been highly conserved throughout evolution.

1. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proc. Natl. Acad. Sci. U.S.A. 92, 7090-4
2. Structures and mechanisms of glycosyl hydrolases. Structure 3, 853-9
3. Molecular analysis of the neutral trehalase gene from Saccharomyces cerevisiae. J. Biol. Chem. 268, 4766-74