InterPro domain: IPR001563

This group of serine peptidases belong to MEROPS peptidase family S10 (clan SC). The type example is carboxypeptidase Y from Saccharomyces cerevisiae (Baker's yeast) [ 1 ].

All known carboxypeptidases are either metallo carboxypeptidases or serine carboxypeptidases ( 3.4.16.5 and 3.4.16.6 ). The catalytic activity of the serine carboxypeptidases, like that of the trypsin family serine proteases, is provided by a charge relay system involving an aspartic acid residue hydrogen-bonded to a histidine, which is itself hydrogen-bonded to a serine [ 2 ]. The sequences surrounding the active site serine and histidine residues are highly conserved in all the serine carboxypeptidases.

1. Families of serine peptidases. Meth. Enzymol. 244, 19-61
2. Structure of wheat serine carboxypeptidase II at 3.5-A resolution. A new class of serine proteinase. J. Biol. Chem. 265, 6528-31