InterPro domain: IPR001519
General Information
- Identifier IPR001519
- Description Ferritin
- Number of genes 423
- Gene duplication stats Loading...
- Associated GO terms GO:0006879 GO:0008199 GO:0006826
Abstract
Ferritin is one of the major non-haem iron storage proteins in animals, plants, and microorganisms [ 1 , 2 ]. It consists of a mineral core of hydrated ferric oxide, and a multi-subunit protein shell which encloses the former and assures its solubility in an aqueous environment.
In animals the protein is mainly cytoplasmic and there are generally two or more genes that encode closely related subunits (in mammals there are two subunits which are known as H(eavy) and L(ight)). In plants ferritin is found in the chloroplast [ 3 ].
1. Iron transport and storage. Eur. J. Biochem. 164, 485-506
2. Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms. Annu. Rev. Biochem. 56, 289-315
3. Evidence for conservation of ferritin sequences among plants and animals and for a transit peptide in soybean. J. Biol. Chem. 265, 18339-44