InterPro domain: IPR001509

General Information

  • Identifier IPR001509
  • Description NAD-dependent epimerase/dehydratase
  • Number of genes 4408
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003824  

Abstract

This domain is found in proteins that utilise NAD as a cofactor and use nucleotide-sugar substrates for a variety of chemical reactions [ 1 ]. One of the best studied of these proteins is UDP-galactose 4-epimerase which catalyses the conversion of UDP-galactose to UDP-glucose during galactose metabolism [ 2 , 3 ].


1. Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Biochemistry 36, 6294-304
2. Human UDP-galactose 4-epimerase. Accommodation of UDP-N-acetylglucosamine within the active site. J. Biol. Chem. 276, 15131-6
3. Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase. Biochemistry 39, 5691-701

Species distribution

Gene table