InterPro domain: IPR001474
General Information
- Identifier IPR001474
- Description GTP cyclohydrolase I
- Number of genes 202
- Gene duplication stats Loading...
- Associated GO terms GO:0003934 GO:0046654
Abstract
GTP cyclohydrolase I ( 3.5.4.16 ) catalyses the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP [ 1 ]. This reaction is the first step in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects. The comparison of the sequence of the enzyme from bacterial and eukaryotic sources shows that the structure of this enzyme has been extremely well conserved throughout evolution [ 2 ].
1. Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. J. Mol. Biol. 326, 503-16
2. Homology cloning of GTP-cyclohydrolase I from various unrelated eukaryotes by reverse-transcription polymerase chain reaction using a general set of degenerate primers. Biochem. Biophys. Res. Commun. 212, 705-11