InterPro domain: IPR001267

Thymidine kinase (TK) ( 2.7.1.21 ) is an ubiquitous enzyme that catalyzes the ATP-dependent phosphorylation of thymidine.

Two different families of thymidine kinase have been identified [ 1 , 2 ] and are represented in this entry; one groups together thymidine kinase from herpesviruses, as well as cytosolic thymidylate kinases and the second family groups thymidine kinase from various sources that include, vertebrates, bacteria, the bacteriophage T4, poxviruses, African swine fever virus (ASFV) and fish lymphocystis disease virus (FLDV). The major capsid protein of insect iridescent viruses also belongs to this family.

1. Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases. Virology 156, 355-65
2. Sequence and evolutionary relationships of African swine fever virus thymidine kinase. Virology 178, 301-4