InterPro domain: IPR001130

This entry represents the TatD family, which includes TatD and many putative deoxyribonucleases and metal-dependent hydrolases. The family is related to a large superfamily of metalloenzymes [ 1 ]. TatD has been shown to be a 3'-5' exonuclease that processes single-stranded DNA in DNA repair [ 2 , 3 ].

In E. coli TatD is encoded by a operon that encodes Tat proteins, including TatA, TatB, and TatC, for protein transport via the Tat (Twin-Arginine Translocation) pathway. However, TatD is not involved in the protein export in the Tat pathway [ 4 ].

1. An evolutionary treasure: unification of a broad set of amidohydrolases related to urease. Proteins 28, 72-82
2. TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export. J. Biol. Chem. 275, 16717-22
3. Structure and function of TatD exonuclease in DNA repair. Nucleic Acids Res. 42, 10776-85