InterPro domain: IPR001093
General Information
- Identifier IPR001093
- Description IMP dehydrogenase/GMP reductase
- Number of genes 205
- Gene duplication stats Loading...
- Associated GO terms GO:0003824
Abstract
Synonym(s): Inosine-5'-monophosphate dehydrogenase, Inosinic acid dehydrogenase; Synonym(s): Guanosine 5'-monophosphate oxidoreductase
This entry contains two related enzymes: IMP dehydrogenase and GMP reductase. These enzymes adopt a TIM barrel structure.
IMP dehydrogenase ( 1.1.1.205 ) (IMPDH) catalyses the rate-limiting reaction of de novo GTP biosynthesis, the NAD-dependent reduction of IMP into XMP [ 1 ].
GMP reductase ( 1.7.1.7 ) catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP [ 3 ].
1. Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs. J. Biol. Chem. 263, 15769-72
2. Two distinct cDNAs for human IMP dehydrogenase. J. Biol. Chem. 265, 5292-5
3. Nucleotide sequence of the gene encoding the GMP reductase of Escherichia coli K12. Biochem. J. 255, 35-43