InterPro domain: IPR001087
General Information
- Identifier IPR001087
- Description GDSL lipase/esterase
- Number of genes 10622
- Gene duplication stats Loading...
- Associated GO terms GO:0016788
Abstract
GDSL esterases and lipases are hydrolytic enzymes with multifunctional properties [ 1 ]. This new subclass of lipolytic enzymes possesses a distinct GDSL sequence motif different from the GxSxG motif found in many lipases [ 2 ]. Members include; Aeromonas hydrophila lipase, Vibrio mimicus arylesterase, Vibrio parahaemolyticus thermolabile haemolysin, rabbit phospholipase (AdRab-B), and Brassica napus anter-specific proline-rich protein. 3D structures of several enzymes of this family revealed several beta-strands and alpha-helices arranged in alternating order and the substrate-binding pocket between the central beta-strand and long alpha-helix appears to be highly flexible [ 3 ].
1. GDSL family of serine esterases/lipases. Prog. Lipid Res. 43, 534-52
2. A new family of lipolytic enzymes? Trends Biochem. Sci. 20, 178-9
3. Identification and biochemical characterization of a GDSL-motif carboxylester hydrolase from Carica papaya latex. Biochim Biophys Acta 1791, 1048-56