InterPro domain: IPR001078
General Information
- Identifier IPR001078
- Description 2-oxoacid dehydrogenase acyltransferase, catalytic domain
- Number of genes 947
- Gene duplication stats Loading...
- Associated GO terms GO:0016746
Abstract
This domain is found in the lipoamide acyltransferase component of the branched-chain alpha-keto acid dehydrogenase complex 2.3.1 , which catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide [ 1 ]. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamideacyltransferase (E2) and lipoamide dehydrogenase (E3). The domain is also found in the dihydrolipoamide succinyltransferase component of the 2-oxoglutarate dehydrogenase complex 2.3.1.61 .These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.
1. Refined crystal structure of the catalytic domain of dihydrolipoyl transacetylase (E2p) from Azotobacter vinelandii at 2.6 A resolution. J. Mol. Biol. 230, 1183-99