InterPro domain: IPR001078

General Information

  • Identifier IPR001078
  • Description 2-oxoacid dehydrogenase acyltransferase, catalytic domain
  • Number of genes 947
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016746  

Abstract

This domain is found in the lipoamide acyltransferase component of the branched-chain alpha-keto acid dehydrogenase complex 2.3.1 , which catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide [ 1 ]. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamideacyltransferase (E2) and lipoamide dehydrogenase (E3). The domain is also found in the dihydrolipoamide succinyltransferase component of the 2-oxoglutarate dehydrogenase complex 2.3.1.61 .These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.


1. Refined crystal structure of the catalytic domain of dihydrolipoyl transacetylase (E2p) from Azotobacter vinelandii at 2.6 A resolution. J. Mol. Biol. 230, 1183-99

Species distribution

Gene table

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