InterPro domain: IPR001055

Adrenodoxin, putidaredoxin and terpredoxin are soluble 2Fe-2S iron-sulphur proteins that act as single electron carriers. They are a subgroup of the ferredoxin family of iron-sulphur proteins.

In mitochondrial monooxygenase systems, adrenodoxin transfers an electron from NADPH:adrenodoxin reductase to membrane-bound P450 [ 1 , 2 ]. In bacteria, putidaredoxin and terpredoxin serve as electron carriers between corresponding NADH-dependent ferredoxin reductases and soluble P450 [ 3 , 4 ]. The exact functions of other members of this family are not known.

1. Adrenodoxin--a versatile ferredoxin. IUBMB Life 64, 506-12
2. A new electron transport mechanism in mitochondrial steroid hydroxylase systems based on structural changes upon the reduction of adrenodoxin. Biochemistry 41, 7969-78
3. Putidaredoxin reductase and putidaredoxin. Cloning, sequence determination, and heterologous expression of the proteins. J. Biol. Chem. 265, 6066-73
4. Cytochrome P-450terp. Isolation and purification of the protein and cloning and sequencing of its operon. J. Biol. Chem. 267, 14193-203