InterPro domain: IPR001040
General Information
- Identifier IPR001040
- Description Translation Initiation factor eIF- 4e
- Number of genes 506
- Gene duplication stats Loading...
- Associated GO terms GO:0003743 GO:0003723 GO:0006413
Abstract
Eukaryotic translation initiation factor 4E (eIF-4E) [ 1 ] is a protein thatbinds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and bindsthe 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiationof protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwindingof its secondary structures. A tryptophan in the central part of the sequence of humaneIF-4E seems to be implicated in cap-binding [ 2 ].
1. Cap recap: the involvement of eIF-4F in regulating gene expression. Cell 68, 177-180
2. Combination of Trp and Glu residues for recognition of mRNA cap structure. Analysis of m7G base recognition site of human cap binding protein (IF-4E) by site-directed mutagenesis. FEBS Lett. 280, 207-10