InterPro domain: IPR001034
General Information
- Identifier IPR001034
- Description DeoR-type HTH domain
- Number of genes 8
- Gene duplication stats Loading...
- Associated GO terms GO:0003700 GO:0006355
Abstract
The deoR-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain ofvabout 50-60 amino acids present in transcription regulators of the deoR family, involved in sugar catabolism. This family of prokaryotic regulators is named after the Escherichia coli protein DeoR, a repressor of the deo operon, which encodes nucleotide and deoxyribonucleotide catabolic enzymes. DeoR also negatively regulates the expression of nupG and tsx, a nucleoside-specific transport protein and a channel-forming protein, respectively.
DeoR-like transcription repressors occur in diverse bacteria as regulators of sugar and nucleoside metabolic systems. The effector molecules for deoR-like regulators are generally phosphorylated intermediates of the relevant metabolic pathway. The DNA-binding deoR-type HTH domain occurs usually in the N-terminal part. The C-terminal part can contain an effector-binding domain and/or an oligomerisation domain. DeoR occurs as an octamer, whilst glpR and agaR are tetramers. Several operators may be bound simultaneously, which could facilitate DNA looping [ 1 , 2 ].
It is worth noting that the DeoR in this entry is represented by the protein, UniProt P0ACK5 , from E. coli. Not the DeoR, UniProt P39140 , from Bacillus subtilis. Despite sharing the same name, these two proteins do not share protein sequence similarity [ 3 ].
1. Opine catabolism and conjugal transfer of the nopaline Ti plasmid pTiC58 are coordinately regulated by a single repressor. Proc. Natl. Acad. Sci. U.S.A. 89, 643-7
2. Application of AgaR repressor and dominant repressor variants for verification of a gene cluster involved in N-acetylgalactosamine metabolism in Escherichia coli K-12. Mol. Microbiol. 51, 813-26
3. Purification and characterization of the DeoR repressor of Bacillus subtilis. J. Bacteriol. 182, 1916-22