InterPro domain: IPR001025
General Information
- Identifier IPR001025
- Description Bromo adjacent homology (BAH) domain
- Number of genes 1941
- Gene duplication stats Loading...
- Associated GO terms GO:0003682
Abstract
The BAH (bromo-adjacent homology) is commonly found in chromatin-associated proteins [ 1 ]. It is found in proteins such as eukaryotic DNA (cytosine-5) methyltransferases IPR001525 , the origin recognition complex 1 (Orc1) proteins, as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialised in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH module might therefore play an important role by linking DNA methylation, replication and transcriptional regulation [ 2 ].
1. The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic Acids Res. 41, 9168-82
2. The BAH (bromo-adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulation. FEBS Lett. 446, 189-93