InterPro domain: IPR000801

This family contains several seemingly unrelated proteins, including human esterase D 3.1.2.12 ; mycobacterial antigen 85 [ 1 ], which is responsible for the high affinity of mycobacteria to fibronectin; Corynebacterium glutamicum major secreted protein PS1; and a number of proteins from Escherichia coli, yeast, mycobacteria and Haemophilus influenzae. Proteins in this entry share the typical AB hydrolase fold including esterases with broad specificity. Among them, S-formylglutathione hydrolases, such as YeiG and FrmB from bacteria 3.1.2.12 ; the three related serine hydrolases Iron(III) enterobactin esterase fes ( 3.1.1.108 ), Iron(III) salmochelin esterase iroD ( 3.1.1.109 ) and iroE ( 3.1.1.107 ) from E. coli which are esterases for the apo and Fe3-bound forms of enterobactin iroB [ 2 , 3 ].

1. Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Biol. 7, 141-6
2. In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. J Am Chem Soc 127, 11075-84
3. Structural characterization of enterobactin hydrolase IroE. Biochemistry 45, 10184-90