InterPro domain: IPR000791

This family of evolutionary related proteins includes Yarrowia lipolytica (Candida lipolytica) glyxoxylate pathway regulator GPR1 [ 1 ], Saccharomyces cerevisiae Ady2 and Fun34 (also known as Ato2); fission yeast hypothetical protein SpAC5D6.09c; Escherichia coli SatP (YaaH); and Aspergillus nidulans AcpA (AN5226). They are predicted to contain six transmembrane regions that may be involved in transport.

Saccharomyces cerevisiae Ady2 is necessary for the expression of an acetate permease [ 2 ]. Gpr1p affects sensitivity to acetic acid in the yeast Yarrowia lipolytica [ 3 ]. AcpA may be a acetate transporter that is essential for acetate permease activity in the hyphal fungus Aspergillus nidulans [ 4 ]. SatP is involved in the uptake of acetate and succinate [ 5 ].

1. Characterization of mutants of the yeast Yarrowia lipolytica defective in acetyl-coenzyme A synthetase. Yeast 8, 193-203
2. Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae. Yeast 21, 201-10
3. Characterization, localization and functional analysis of Gpr1p, a protein affecting sensitivity to acetic acid in the yeast Yarrowia lipolytica. Microbiology (Reading, Engl.) 149, 589-600
4. AcpA, a member of the GPR1/FUN34/YaaH membrane protein family, is essential for acetate permease activity in the hyphal fungus Aspergillus nidulans. Biochem. J. 412, 485-93
5. SATP (YaaH), a succinate-acetate transporter protein in Escherichia coli. Biochem. J. 454, 585-95