InterPro domain: IPR000751

General Information

  • Identifier IPR000751
  • Description M-phase inducer phosphatase

Abstract

M-phase inducer phosphatases function as dosage-dependent inducers in mitotic control [ 1 , 2 , 3 , 4 ]. They are tyrosine protein phosphatases required for progression of the cell cycle. They may directly dephosphorylate p34(cdc2) and activate p34(cdc2) kinase activity. They catalyse the reaction:

protein tyrosine phosphate + H 2 O = protein tyrosine + P i


1. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell 67, 1181-94
2. Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string. EMBO J. 9, 3565-71
3. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J. 13, 1549-56
4. Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity. Mol. Biol. Cell 3, 927-39

Species distribution

Gene table