InterPro domain: IPR000631

General Information

  • Identifier IPR000631
  • Description ATP-dependent (S)-NAD(P)H-hydrate dehydratase
  • Number of genes 146
  • Gene duplication stats Loading...
  • Associated GO terms GO:0052855  

Abstract

Hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase. The ATP-dependent dehydratase has been identified as the product of the vertebrate Carkd (carbohydrate kinase domain) gene [ 1 ]. In E. coli, it is found as the C-terminal domain of a bifunctional enzyme (YjeF) that also includes the epimerase and uses ADP instead of ATP [ 2 ]. These enzymes are widespread in eukaryotes, prokaryotes, and archaea.


1. Occurrence and subcellular distribution of the NADPHX repair system in mammals. Biochem. J. 460, 49-58
2. Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. J. Biol. Chem. 286, 41246-52

Species distribution

Gene table