InterPro domain: IPR000577
General Information
- Identifier IPR000577
- Description Carbohydrate kinase, FGGY
- Number of genes 366
- Gene duplication stats Loading...
- Associated GO terms GO:0005975 GO:0016773
Abstract
FGGY carbohydrate kinases carry out ATP-dependent phosphorylation on one out of at least nine distinct sugar substrates [ 1 ]. These enzymes include L-ribulokinase ( 2.7.1.16 ) (gene araB); Erythriol kinase ( 2.7.1.27 ) (gene eryA); L-fucolokinase ( 2.7.1.51 ) (gene fucK); gluconokinase ( 2.7.1.12 ) (gene gntK); glycerol kinase ( 2.7.1.30 ) (gene glpK); xylulokinase ( 2.7.1.17 ) (gene xylB); L-xylulose kinase ( 2.7.1.53 ) (gene lyxK), D-ribulokinase ( 2.7.1.47 ) (gene rbtK); and rhamnulokinase ( 2.7.1.5 ) (gene rhaB). This family also contains a divergent subfamily functioning in quorum sensing, which phosphorylates AI-2, a bacterial signaling molecule derived from 4,5-dihydroxy-2,3-pentanedione (DPD) [ 2 ].
1. The FGGY carbohydrate kinase family: insights into the evolution of functional specificities. PLoS Comput. Biol. 7, e1002318
2. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem. Biol. 2, 128-36