InterPro domain: IPR000558
General Information
- Identifier IPR000558
- Description Histone H2B
- Number of genes 1195
- Gene duplication stats Loading...
- Associated GO terms GO:0003677 GO:0000786
Abstract
Histone H2B is one of the five histones, along with H1/H5, H2A, H3 and H4. Two copies of each of the H2A, H2B, H3, and H4 histones ensemble to form the core of the nucleosome [ 1 ]. The nucleosome forms octameric structure that wraps DNA in a left-handed manner. Histones can undergo several different types of post-translational modifications that affect transcription, DNA repair, DNA replication and chromosomal stability.
The HBR (histone H2B repression) domain within the H2B N terminus is important for nucleosome assembly by histone chaperone FACT [ 2 ].
1. Recognition and classification of histones using support vector machine. J. Comput. Biol. 13, 102-12
2. A basic domain in the histone H2B N-terminal tail is important for nucleosome assembly by FACT. Nucleic Acids Res. 44, 9142-9152