InterPro domain: IPR000522
General Information
- Identifier IPR000522
- Description ABC transporter, permease protein, BtuC-like
- Number of genes 4
- Gene duplication stats Loading...
- Associated GO terms GO:0022857 GO:0016020
Abstract
This entry represents a family of ABC transporter permease proteins. It includes the vitamin B12 import system permease protein BtuC, and the Fe(3+) dicitrate transport system permease proteins FecC and FecD, among many others.
BtuC is a component of the ABC transporter complex BtuCD, which facilitates uptake of vitamin B12 into the cytoplasm of Escherichia coli [ 1 ].
FecC and FecD are components of of the fec operon, a Periplasmic-Binding-Protein (PBP)-dependent transport system for ferric dicitrate in Escherichia coli [ 2 ]. FecC and FecD exhibit homology to each other and are localized in the cytoplasmic membrane.
1. In vitro functional characterization of BtuCD-F, the Escherichia coli ABC transporter for vitamin B12 uptake. Biochemistry 44, 16301-9
2. Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli. J. Bacteriol. 171, 2626-33