InterPro domain: IPR000438
General Information
- Identifier IPR000438
- Description Acetyl-CoA carboxylase carboxyl transferase, beta subunit
- Number of genes 186
- Gene duplication stats Loading...
- Associated GO terms GO:0003989 GO:0006633 GO:0009317
Abstract
Fatty acid synthesis involves a set of reactions, starting with carboxylation of acetyl-CoA to malonyl-CoA. This is an irreversible reaction, catalysed by the acetyl-CoA carboxylase complex ( 6.4.1.2 ); a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association [ 1 ]. The reaction involves two steps:
- Biotin carrier protein + ATP + HCO 3 - = Carboxybiotin carrier protein + ADP + P i
- Carboxybiotin carrier protein + Acetyl-CoA = Malonyl-CoA + Biotin carrier protein
In the first step, biotin carboxylase catalyses the carboxylation of the carrier protein to form an intermediate. Next, the transcarboxylase complex transfers the carboxyl group from the intermediate to acetyl-CoA forming malonyl-CoA.
1. The genes encoding the two carboxyltransferase subunits of Escherichia coli acetyl-CoA carboxylase. J. Biol. Chem. 267, 16841-7