Gene: Sopen03g027640

General Information

Description The FUSED (FU) gene belongs to Ser/Thr protein kinase family and has a key role in the hedgehog signaling pathway known to control cell proliferation and patterning in fruit flies and humans . Arabidopsis thaliana genome has a single Fu gene. Cytokinesis-defective mutants, which we named two-in-one (tio), result from mutations in Arabidopsis Fu. Phenotypic analysis of tio mutants reveals an essential role for TIO in conventional modes of cytokinesis in plant meristems and during male gametogenesis. TIO is tightly localized to the midline of the nascent phragmoplast and remains associated with the expanding phragmoplast ring. This gene was previously annotated as two gene models, AT1G50230.1 and AT1G50240.1, however the experimental evidence exists (Oh et al, Current Biology, 2005) showing that these two models are in fact single gene, named FUSED. | FUSED (FU) | CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site , Serine/threonine-protein kinase domain , Armadillo-like helical , Armadillo , 26S proteasome non-ATPase regulatory subunit 5 , Serine/threonine-protein kinase-like domain , Protein kinase-like domain , Serine/threonine-protein kinase, active site , Protein kinase, catalytic domain , Armadillo-type fold | BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 2

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0006468	IEA	InterPro	protein phosphorylation
GO:0000911	ISO	PLAZA Integrative Orthology	cytokinesis by cell plate formation	AT1G50240
GO:0007112	ISO	PLAZA Integrative Orthology	male meiosis cytokinesis	AT1G50240
GO:0009558	ISO	PLAZA Integrative Orthology	embryo sac cellularization	AT1G50240

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0004672	IEA	InterPro	protein kinase activity
GO:0005524	IEA	InterPro	ATP binding
GO:0005515	ISO	PLAZA Integrative Orthology	protein binding	AT1G50240
GO:0019894	ISO	PLAZA Integrative Orthology	kinesin binding	AT1G50240

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0009524	ISO	PLAZA Integrative Orthology	phragmoplast	AT1G50240

Experimental Evidence

Computational Reviewed Evidence

Electronic Evidence

InterPro	Description
IPR016024	Armadillo-type fold
IPR011009	Protein kinase-like domain superfamily
IPR000719	Protein kinase domain
IPR011989	Armadillo-like helical

Mapman id	Description
13.4.3.2	Cell cycle organisation.cytokinesis.phragmoplast microtubule organization.Kinesin-12-regulating protein kinase (TIO)
18.4.17	Protein modification.phosphorylation.protein kinase (ULK)