Gene: AT4G21070

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT4G21070
  • Transcript Identifier AT4G21070.1
  • Gene Type Coding gene
  • Location Chr4 : 11248174-11252633 : positive

Gene Family Information

  • ID HOM05D000001
  • #Genes/#Species 35287/100
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT4G21070.1
  • symbol BRCA1
  • Alias ATBRCA1,ARABIDOPSIS THALIANA BREAST CANCER SUSCEPTIBILITY1
  • uniprot Q8RXD4

Descriptions

  • Description breast cancer susceptibility1
  • Computational description breast cancer susceptibility1 (BRCA1); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: DNA repair, response to gamma radiation; LOCATED IN: intracellular, nucleus; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), BRCA1 (InterPro:IPR011364), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: breast cancer associated RING 1 (TAIR:AT1G04020.2); Has 8999 Blast hits to 8407 proteins in 1134 species: Archae - 0; Bacteria - 191; Metazoa - 6557; Fungi - 520; Plants - 721; Viruses - 32; Other Eukaryotes - 978 (source: NCBI BLink).
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Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000724
IMP
IBA
Gene Ontologydouble-strand break repair via homologous recombination1 2
GO:0006974
IEA
GOA Databasecellular response to DNA damage stimulus
GO:0006974
IEA
InterProcellular response to DNA damage stimulus
GO:0006281
IEA
GOA DatabaseDNA repair
GO:0006281
IMP
Gene OntologyDNA repair1
GO:0006281
IEA
InterProDNA repair
GO:0016567
IEA
GOA Databaseprotein ubiquitination
GO:0035066
IBA
Gene Ontologypositive regulation of histone acetylation2
GO:0035067
IBA
Gene Ontologynegative regulation of histone acetylation2
GO:0045717
IBA
Gene Ontologynegative regulation of fatty acid biosynthetic process2
GO:0045944
IBA
Gene Ontologypositive regulation of transcription by RNA polymerase II2
GO:0006310
IMP
Gene OntologyDNA recombination3
GO:0071480
IEP
Gene Ontologycellular response to gamma radiation1
GO:0010332
IEP
Gene Ontologyresponse to gamma radiation4

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046872
IEA
GOA Databasemetal ion binding
GO:0004842
IDA
IBA
Gene Ontologyubiquitin-protein transferase activity2 5
GO:0005515
IPI
Gene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
GOA Databasenucleus
GO:0005634
IDA
ISM
Gene Ontologynucleus1
GO:0031436
IBA
Gene OntologyBRCA1-BARD1 complex2
GO:0070531
IBA
Gene OntologyBRCA1-A complex2
GO:0005886
IBA
Gene Ontologyplasma membrane2

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR001357 BRCT domain
IPR036420 BRCT domain superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-type
IPR001841 Zinc finger, RING-type
IPR031099 BRCA1-associated
Mapman id Description
14.3.1.1 DNA damage response.homologous recombination repair (HR).BRCA1-BARD1 DNA-damage response heterodimer.component BRCA1/BARD1