Gene: AT3G18524

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT3G18524
  • Transcript Identifier AT3G18524.1
  • Gene Type Coding gene
  • Location Chr3 : 6368151-6372409 : negative

Gene Family Information

  • ID HOM05D001061
  • #Genes/#Species 575/100
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT3G18524.1
  • symbol MSH2
  • Alias ATMSH2
  • uniprot O24617

Descriptions

  • Description MUTS homolog 2
  • Computational description MUTS homolog 2 (MSH2); FUNCTIONS IN: damaged DNA binding, protein binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, negative regulation of reciprocal meiotic recombination; LOCATED IN: plasma membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695), DNA mismatch repair protein, MSH2 (InterPro:IPR011184); BEST Arabidopsis thaliana protein match is: homolog of DNA mismatch repair protein MSH3 (TAIR:AT4G25540.1); Has 13560 Blast hits to 13453 proteins in 2654 species: Archae - 128; Bacteria - 8942; Metazoa - 734; Fungi - 813; Plants - 457; Viruses - 3; Other Eukaryotes - 2483 (source: NCBI BLink).
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Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006281
IEA
GOA DatabaseDNA repair
GO:0006974
IEA
GOA Databasecellular response to DNA damage stimulus
GO:0043570
IBA
Gene Ontologymaintenance of DNA repeat elements1
GO:0006298
IEA
GOA Databasemismatch repair
GO:0006298
IMP
IBA
Gene Ontologymismatch repair1 2
GO:0006298
IEA
InterPromismatch repair
GO:0045128
IMP
Gene Ontologynegative regulation of reciprocal meiotic recombination3
GO:0006290
IMP
Gene Ontologypyrimidine dimer repair4
GO:0045910
IBA
Gene Ontologynegative regulation of DNA recombination1
GO:0006301
IBA
Gene Ontologypostreplication repair1
GO:0006310
IBA
Gene OntologyDNA recombination1

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
GOA Databasenucleotide binding
GO:0008094
IBA
Gene OntologyATPase, acting on DNA1
GO:0032181
IBA
Gene Ontologydinucleotide repeat insertion binding1
GO:0003677
IEA
GOA DatabaseDNA binding
GO:0003677
IEA
InterProDNA binding
GO:0005524
IEA
GOA DatabaseATP binding
GO:0005524
IEA
InterProATP binding
GO:0030983
IEA
GOA Databasemismatched DNA binding
GO:0030983
IDA
Gene Ontologymismatched DNA binding5
GO:0030983
IEA
InterPromismatched DNA binding
GO:0000400
IBA
Gene Ontologyfour-way junction DNA binding1
GO:0003684
IDA
Gene Ontologydamaged DNA binding6
GO:0005515
IPI
Gene Ontologyprotein binding6
GO:0032142
IBA
Gene Ontologysingle guanine insertion binding1
GO:0032357
IBA
Gene Ontologyoxidized purine DNA binding1
GO:0032143
IBA
Gene Ontologysingle thymine insertion binding1
GO:0032405
IBA
Gene OntologyMutLalpha complex binding1
GO:0000406
IBA
Gene Ontologydouble-strand/single-strand DNA junction binding1
GO:0032137
IBA
Gene Ontologyguanine/thymine mispair binding1

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032302
IBA
Gene OntologyMutSbeta complex1
GO:0032301
IBA
Gene OntologyMutSalpha complex1
GO:0005634
IEA
GOA Databasenucleus
GO:0005634
ISM
Gene Ontologynucleus
GO:0005886
IDA
GOA Databaseplasma membrane
GO:0005886
HDA
Gene Ontologyplasma membrane7
GO:0032300
IEA
GOA Databasemismatch repair complex
GO:0032300
IBA
Gene Ontologymismatch repair complex1
GO:0032300
IEA
InterPromismatch repair complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR000432 DNA mismatch repair protein MutS, C-terminal
IPR007861 DNA mismatch repair protein MutS, clamp
IPR036678 MutS, connector domain superfamily
IPR007696 DNA mismatch repair protein MutS, core
IPR036187 DNA mismatch repair protein MutS, core domain superfamily
IPR007860 DNA mismatch repair protein MutS, connector domain
IPR016151 DNA mismatch repair protein MutS, N-terminal
IPR007695 DNA mismatch repair protein MutS-like, N-terminal
IPR045076 DNA mismatch repair MutS family
IPR032642 DNA mismatch repair protein Msh2
IPR011184 DNA mismatch repair Msh2-type
Mapman id Description
14.7.1.1 DNA damage response.mismatch repair (MMR).MSH2-x mismatch repair heterodimer components.component MSH2