| AT3G19150 | KIP-related protein 6 KIP-related protein 6 (KRP6); FUNCTIONS IN: cyclin binding, cyclin-dependent protein kinase inhibitor activity; INVOLVED IN: negative regulation of cyclin-dependent protein kinase activity, DNA endoreduplication; LOCATED IN: nucleus; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: D pollen mother cell meiosis stage, C tetrad of megaspores, B meiosis of megaspore mother cell; CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701), Cyclin-dependent kinase inhibitor (InterPro:IPR003175); BEST Arabidopsis thaliana protein match is: Cyclin-dependent kinase inhibitor family protein (TAIR:AT1G49620.1); Has 1712 Blast hits to 484 proteins in 111 species: Archae - 0; Bacteria - 136; Metazoa - 266; Fungi - 200; Plants - 207; Viruses - 3; Other Eukaryotes - 900 (source: NCBI BLink). Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI), negative regulator of cell division. Binds to D type cyclins. A member of seven KRP genes found in Arabidopsis thaliana. Differential expression patterns for distinct KRPs were revealed by in situ hybridization. KRP6 appears to be targeted for degradation by RHF1a and RHF2a to allow mitotic divisions during gametogenesis. In addition, KRP6 transcript levels rise prior to and drop following the meitotic divisions of gametogenesis. Elevated levels of KRP6 negatively affect plant development and fertility. | 3 | - | View |
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