Module
- Number
- 100
- Regulatory Genes
- 4
- Module Genes
- 21
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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2L52.1 | 2L52.1 | WBGene00007063 | 658 |
2L52.1 encodes a protein with sequence similarity to GLI-family zinc-finger transcription factors; deletion mutations in 2L52.1 are reported to be homozygous viable.
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fos-1 | F29G9.4 | WBGene00001345 | 167 |
fos-1 encodes two basic region-leucine zipper (bZip) transcription factors, FOS-1A and FOS-1B, that are the sole C. elegans orthologs of the fos bZip transcription factor family; during hermaphrodite development, FOS-1A activity is required cell autonomously in the gonadal anchor cell for basement-membrane removal and subsequent anchor cell invasion of the vulval epithelium; in addition, fos-1 activity is also required for proper vulval and uterine development, fertility, and oogenesis; in late-L3 larvae, a FOS-1A translational fusion protein is expressed at high levels in the anchor cell nucleus and at lower levels in uterine cells, while a FOS-1B reporter is expressed at low levels in the anchor cell, uterine, and vulval cells; transcriptional reporters additionally reveal that fos-1b is expressed in most cells of late L3 larvae; in affecting anchor cell invasion, FOS-1A appears to act by regulating the expression of three AC-expressed genes: cdh-3/cadherin, him-4/hemicentin, and zmp-1/matrix metalloproteinase, which likely function together to promote anchor cell invasion.
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pik-1 | K09B11.1 | WBGene00004029 | 156 |
The pik-1 gene encodes a pelle/IRAK kinase homolog that may be involved in apoptosis.
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fkh-5 | F26A1.2 | WBGene00001437 | 105 |
fkh-5 encodes a member of the forkhead domain transcription factor family.
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CLR Predictions
10 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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2L52.1 | 2L52.1 | WBGene00007063 |
2L52.1 encodes a protein with sequence similarity to GLI-family zinc-finger transcription factors; deletion mutations in 2L52.1 are reported to be homozygous viable.
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B0034.2 | B0034.2 | WBGene00015003 | View | |
B0250.7 | B0250.7 | WBGene00007124 | View | |
C04E7.3 | C04E7.3 | WBGene00015430 | View | |
C09H10.7 | C09H10.7 | WBGene00007501 | View | |
cyn-16 | Y17G7B.9 | WBGene00000892 |
cyn-16 encodes a highly diverged member of the cyclophilin family; CYN-16 exhibits low levels of peptidyl-prolyl cis/trans isomerase activity in vitro that is insensitive to the presence of cyclosporin A; a cyn-16::gfp fusion protein is expressed in the intestine during larval and adult stages of development, with particularly strong expression seen in the anterior and posterior ends; in dauer larvae, the cyn-16::gfp reporter is expressed in cell bodies and processes of ventral cord neurons and is no longer visible in the intestine.
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F07H5.6 | F07H5.6 | WBGene00008557 | View | |
F12A10.7 | F12A10.7 | WBGene00017396 | View | |
F28B3.4 | F28B3.4 | WBGene00017885 | View | |
F53C3.7 | F53C3.7 | WBGene00018751 | View | |
F55F10.1 | F55F10.1 | WBGene00018898 | View | |
odd-1 | B0280.4 | WBGene00003845 |
odd-1 encodes a C2H2-type zinc finger-containing transcription factor similar to Drosophila odd skipped which is required for embryonic patterning; ODD-1 is expressed in the gut during embryogenesis and appears to be essential for larval development.
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pik-1 | K09B11.1 | WBGene00004029 |
The pik-1 gene encodes a pelle/IRAK kinase homolog that may be involved in apoptosis.
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R02F2.6 | R02F2.6 | WBGene00019835 | View | |
srj-8 | T28A11.9 | WBGene00005596 | View | |
T16H12.2 | T16H12.2 | WBGene00011812 | View | |
T28F12.1 | T28F12.1 | WBGene00020904 | View | |
Y39G10AR.11 | Y39G10AR.11 | WBGene00021469 | View | |
Y53F4B.13 | Y53F4B.13 | WBGene00013160 | View | |
Y71G12B.13 | Y71G12B.13 | WBGene00022153 | View | |
Y95B8A.8 | Y95B8A.8 | WBGene00022388 | View |