Module
- Number
- 99
- Regulatory Genes
- 4
- Module Genes
- 21
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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sem-4 | F15C11.1 | WBGene00004773 | 894 |
sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F.
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ceh-33 | C10G8.7 | WBGene00000454 | 162 |
ceh-33 encodes a Six/sine oculis class homeodomain transcription factor; preliminary RNAi experiments suggest that CEH-33 activity may be required for gonad development; a ceh-33::gfp reporter shows very weak pharyngeal expression in late embryos and early larvae.
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nfya-2 | Y53H1A.5 | WBGene00043056 | 130 | View | |
F49E8.2 | F49E8.2 | WBGene00018636 | 105 | View |
CLR Predictions
57 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C18A11.2 | C18A11.2 | WBGene00015948 | View | |
C29F9.1 | C29F9.1 | WBGene00016216 | View | |
C44B7.6 | C44B7.6 | WBGene00016628 | View | |
F18A12.8 | F18A12.8 | WBGene00017557 |
F18A12.8 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.8A is closely paralogous to ZK20.6, and orthologous to CG9761 in Drosophila melanogaster; F18A12.8 is homologous, and possibly orthologous, to human ECE1 (OMIM:600423; mutation leads to Hirschsprung disease, cardiac defects, and autonomic dysfunction); more generally, F18A12.8A falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes).
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F39B2.8 | F39B2.8 | WBGene00009558 | View | |
F46C5.2 | F46C5.2 | WBGene00009779 | View | |
F46G11.4 | F46G11.4 | WBGene00018517 | View | |
M02E1.2 | M02E1.2 | WBGene00019734 | View | |
nas-31 | F58B4.1 | WBGene00003549 | View | |
pqn-25 | D1044.3 | WBGene00004114 |
The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
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R06C1.6 | R06C1.6 | WBGene00011060 | View | |
stn-1 | F30A10.8 | WBGene00006062 | View | |
stn-2 | F27D9.8 | WBGene00017866 | View | |
T28B4.4 | T28B4.4 | WBGene00020887 |
T28B4.4 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; T28B4.4 is worm-specific, weakly similar to CLC-1; T28B4.4 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water.
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tag-178 | B0495.10 | WBGene00007044 | View | |
tag-180 | T24F1.6 | WBGene00007041 | View | |
tsp-7 | T23D8.2 | WBGene00006633 | View | |
wrk-1 | F41D9.3 | WBGene00006942 |
wrk-1 encodes, by alternative splicing, at least three isoforms of a GPI-anchored immunoglobulin superfamily (IgSF) protein orthologous to Drosophila KLINGON, WRAPPER, CG7166, and CG13506; WRK-1 is expressed in the pioneering embryonic motoneurons (eMNs) DA, DB, and DD; WRK-1 expression in DA, DB, and DD is necessary and sufficient to prevent follower axons from inappropriately crossing the ventral midline; WRK-1 also retards developmental changes in the outward current of maturing AIY interneurons; in addition to eMNs and AIY neurons, WRK-1 is expressed in ASI and SMDV/D neurons, along with sheath and socket cells, intestine, the excretory gland cell, distal tip cells, and coelomocytes; wrk-1 transcription in AIY requires TTX-3, being greatly reduced in a ttx-3(ot22) mutant background; however, wrk-1 may not be transcriptionally activated by CEH-10/TTX-3 heterodimers, since wrk-1 lacks an AIY motif in its cis-regulatory sequences; WRK-1 binds VAB-1 or VAB-2 in vitro, and wrk-1(ok695) mutations fail to enhance vab-1 or a triple vab-2, efn-2, and efn-3 mutation, indicating that WRK-1 acts in concert with ephrins; wrk-1(ok695) null mutants exhibit midline crossover defects in the axons of HSN, PVQ, AV-type, and PVC neurons; wrk-1(ok695) and wrk-1(tm1099) mutant neurons have normal whole cell capacitance but precociously altered their outward current from a slowly activating, sustained current to a rapidly-activating one; hypodermal misexpression of WRK-1 induces defects in PVQ axonal outgrowth, which are enhanced by a wrk-1(ok695) mutant background; wrk-1(ok695) mutations enhance sax-3(ky123), indicating that WRK-1 and SAX-3 act in parallel.
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Y38C1AA.9 | Y38C1AA.9 | WBGene00021400 | View | |
Y45G5AM.6 | Y45G5AM.6 | WBGene00021558 | View | |
ZK287.1 | ZK287.1 | WBGene00013962 | View |