Module
- Number
- 96
- Regulatory Genes
- 3
- Module Genes
- 19
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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rab-3 | C18A3.6 | WBGene00004267 | 847 |
rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons.
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plc-1 | F31B12.1 | WBGene00004036 | 249 |
plc-1 encodes a predicted phospholipase C that affects fertility and possesses two functional domains not commonly seen in other phospholipases: a C-terminal Ras-associating domain with structural similarity to RalGDS and AF-6, and an N-terminal CDC25-like domain that possesses structural homology to guanine nucleotide exchange proteins for Ras.
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gpa-14 | B0207.3 | WBGene00001676 | 162 |
gpa-14 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; gpa-14 is expressed in ASI, ASJ, ASH, ASK, ADE, PHA, PHB ALA, AVA, CAN, DVA, PVQ, RIA, and in vulval muscle, and also exhibits faint expression in the vulval hypodermis.
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CLR Predictions
26 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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acr-15 | F25G6.4 | WBGene00000054 |
A homolog of an alpha type nicotinic acetylcholine receptor subunit involved in the mediation of fast synaptic transmission at neuromuscular junctions.
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B0563.7 | B0563.7 | WBGene00015264 | View | |
C16D9.1 | C16D9.1 | WBGene00015857 | View | |
C50C3.5 | C50C3.5 | WBGene00016801 | View | |
ctg-2 | T13H5.2 | WBGene00011756 | View | |
dac-1 | B0412.1 | WBGene00000895 |
dac-1 encodes the C. elegans ortholog of Dachshund, a transcriptional regulator first described in Drosophila that is a member of the SKI/SNO/DAC family of proteins; dac-1 is expressed at higher levels in the AFD thermosensory neurons as compared to the AWB olfactory neurons and likely plays a role in thermosensory behavior as on thermal gradients dac-1 mutants fail to suppress cryophilic drive but continue to track isotherms at the cultivation temperature; a DAC-1::GFP fusion protein is nuclear and expressed strongly in the AFD thermosensory neurons, but weakly in the AWC, ASE, and ASK chemosensory neurons; expression is also seen in alae and additional, unidentified tail cells; dac-1 expression in AFD is positively regulated by the TTX-1 OTX-like homeodomain protein.
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E02A10.3 | E02A10.3 | WBGene00008453 | View | |
F33D11.8 | F33D11.8 | WBGene00018005 | View | |
F35H10.3 | F35H10.3 | WBGene00018069 | View | |
F48F7.5 | F48F7.5 | WBGene00009850 | View | |
fbxa-24 | F54D10.2 | WBGene00018803 | View | |
gpc-1 | K02A4.2 | WBGene00001681 |
The gpc-1 gene encodes a heterotrimeric guanine nucleotide-binding protein gamma subunit, expressed specifically in sensory neurons, that is involved in taste adaptation.
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hot-5 | K07A12.6 | WBGene00001990 |
hot-5 encodes a predicted membrane-associated protein that is a member of the Ly-6 superfamily of glycosylphosphatidylinositol (GPI)-linked signaling proteins and is homologous to ODR-2, a neuronally expressed protein required for olfaction; as loss of hot-5 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of HOT-5 in C. elegans development and/or behavior is not yet known.
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K02A2.5 | K02A2.5 | WBGene00019290 | View | |
pef-1 | F23H11.8 | WBGene00003969 |
pef-1 encodes an ortholog of the rhodopsin-specific serine/threonine phosphatase RdgC in D. melanogaster and of RdgC-related proteins in humans (PPEF1 and PPEF2; OMIM:300109 and OMIM:602256); PEF-1 has a EF-hand calcium-binding domain, and is peripherally bound to the plasma membrane by myristoylation and palmitoylation; pef-1 has no known mutant phenotype, but is expressed in several anterior amphid neurons, from what appears to be the 3-fold embryo stage onward; on the basis of its expression and its orthology, PEF-1 may negatively regulate signalling through serpentine receptors such as STR-2.
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sol-1 | C15A11.3 | WBGene00004944 | View | |
ttr-29 | R90.4 | WBGene00011286 | View | |
twk-43 | F32H5.7 | WBGene00006693 | View | |
twk-8 | ZC410.4 | WBGene00006663 |
twk-8 encodes one of more than 40 TWK (two-P domain K+) potassium channels in C. elegans that contain two pore regions and four transmembrane domains; expressed in body-wall muscle.
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