Module
- Number
- 91
- Regulatory Genes
- 6
- Module Genes
- 14
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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F17A9.3 | F17A9.3 | WBGene00017535 | 380 | View | |
nhr-31 | C26B2.3 | WBGene00003625 | 323 | View | |
rab-3 | C18A3.6 | WBGene00004267 | 298 |
rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons.
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C04F5.9 | C04F5.9 | WBGene00015451 | 197 | View | |
egl-44 | F28B12.2 | WBGene00001208 | 163 |
The egl-44 gene encodes a putative transcription regulatory protein of 471 amino acids similar to vertebrate transcription enhancer factor (TEF) proteins.
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sbp-1 | Y47D3B.7 | WBGene00004735 | 111 |
sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; sbp-1 expression is detected exclusively in the intestine, the major site of fat storage, from early embryogenesis through adulthood.
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CLR Predictions
8 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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F09F9.2 | F09F9.2 | WBGene00017307 | View | |
F33A8.7 | F33A8.7 | WBGene00009355 | View | |
F44E2.4 | F44E2.4 | WBGene00018418 | View | |
grl-7 | T02E9.2 | WBGene00001716 |
grl-7 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-7 is expressed in intestine, hypodermis, and seam cells; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
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H03E18.1 | H03E18.1 | WBGene00019148 | View | |
H10E21.4 | H10E21.4 | WBGene00019184 | View | |
H42K12.3 | H42K12.3 | WBGene00019272 | View | |
ptr-4 | C45B2.7 | WBGene00004219 |
ptr-4 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-4 is strongly required for normal molting from L4 to adult stages male tail development (a role conserved in C. briggsae); PTR-4 is also required for normal endocytosis of yolk by oocytes, adult alae formation, growth to full size, locomotion, and viability.
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qua-1 | T05C12.10 | WBGene00004264 |
qua-1 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Qua domain, a 5W repeat, an extended region of low-complexity sequence, and a Hint/Hog domain; QUA-1 is conserved among nematodes from Caenorhabditis to Brugia; QUA-1 is expressed prior to molting in hyp1 to hyp11 hypodermal cells, but not in seam cells, and ceases to be expressed after each molting cycle or in gravid adults no longer molting; QUA-1 is strongly required for normal molting, with lethal molting defects in qua-1 mutants and severe defects in qua-1(RNAi) animals; similar molting defects in RNAi of ptr-4 and ptr-23 (encoding Dispatched homologs) suggest that PTR-4 and PTR-23 may export QUA-1 from hypodermal cells synthesizing it; other sites of QUA-1 expression include intestinal and rectal cells, excretory duct and pore cells, sensilla support cells, the P cell lineage in L1, body wall muscle, and the adult reproductive system; QUA-1 is also required for normal adult alae formation, growth to full size, cuticle adhesion, locomotion, and male tail development; the Hint/Hog domain is predicted to cut QUA-1 into two halves and then covalently link cholesterol to the C-terminus of the Qua domain; the Qua domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and the Qua domain has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; both Qua and Hint/Hog domains are required for transgenic rescue of a lethal qua-1 allele; defects in both qua-1 mutants and qua-1(RNAi) animals; all of QUA-1's functions may reflect common defects in cholesterol-dependent hedgehog-like signalling.
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R11A5.7 | R11A5.7 | WBGene00011235 | View | |
T06G6.6 | T06G6.6 | WBGene00011548 | View | |
wrt-4 | ZK678.5 | WBGene00006950 |
wrt-4 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Wart domain, an short region of low-complexity sequence, and a Hint/Hog domain; WRT-4 is expressed strongly in hypodermal syncytia hyp6-hyp10 from 3-fold embryos to adults; the Hint/Hog domain is predicted to cut WRT-4 into two halves and then covalently link cholesterol to the C-terminus of the Wart domain; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-4 is weakly required for normal molting; WRT-4 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
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Y102A11A.5 | Y102A11A.5 | WBGene00022415 | View | |
Y11D7A.9 | Y11D7A.9 | WBGene00012433 | View |