Module
- Number
- 87
- Regulatory Genes
- 7
- Module Genes
- 17
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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srg-44 | F31E9.2 | WBGene00005201 | 582 | View | |
srg-41 | T19C4.3 | WBGene00005198 | 474 | View | |
srg-45 | C51F7.2 | WBGene00005202 | 244 | View | |
rab-1 | C39F7.4 | WBGene00004266 | 217 |
rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline.
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srab-2 | C04F5.5 | WBGene00015447 | 131 | View | |
srg-7 | C18F10.8 | WBGene00005165 | 121 | View | |
xbp-1 | R74.3 | WBGene00006959 | 101 |
xbp-1 encodes a bZIP transcription factor orthologous to yeast Hac1 and mammalian X box-binding protein 1 (XBP-1, OMIM:194355); XBP-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); XBP-1 mRNA is spliced by the IRE-1 endoribonuclease to promote translation of transcriptionally active XBP-1 that positively regulates UPR gene expression to maintain ER homeostasis and promote normal development.
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CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C50E3.9 | C50E3.9 | WBGene00016820 | View | |
egl-47 | C50H2.2 | WBGene00001211 |
egl-47 encodes two seven transmembrane G-protein-coupled receptors; while loss-of-function mutations in egl-47 result in no detectable egg-laying defects, gain-of-function mutations and overexpression studies suggest that EGL-47 is required for negatively regulating activity of the hermaphrodite-specific motor neurons (HSNs) that control egg laying; EGL-47::GFP reporters made with either of the two isoforms indicate that EGL-47 is expressed in a small subset of head neurons, the HSNs, and the PVQ tail interneurons; in addition, a reporter made with the longer isoform, EGL-47A, is expressed in vulval cells in L4 larvae; in adults, the only cells of the egg-laying system that express EGL-47 are the HSNs; genetic and overexpression studies suggest that, in the HSNs, EGL-47 signals through the G-alpha protein GOA-1 to inhibit egg laying.
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K09C8.2 | K09C8.2 | WBGene00010715 | View | |
srg-64 | ZK678.6 | WBGene00005221 | View | |
srh-10 | Y38A10A.3 | WBGene00005236 | View | |
srh-115 | Y61B8A.2 | WBGene00005334 | View | |
srh-213 | T22F3.5 | WBGene00005423 | View | |
srh-308 | F58E10.6 | WBGene00010261 | View | |
srh-89 | F25E5.14 | WBGene00005310 | View | |
srsx-3 | Y97E10B.9 | WBGene00022408 | View | |
srsx-6 | Y97E10B.3 | WBGene00022405 | View | |
sru-3 | C33A12.11 | WBGene00005666 | View | |
srw-113 | ZK1037.9 | WBGene00005860 | View | |
srw-130 | T24A6.14 | WBGene00005877 | View | |
srw-93 | F32A7.2 | WBGene00005840 | View | |
T25E4.2 | T25E4.2 | WBGene00020804 | View | |
ZC404.10 | ZC404.10 | WBGene00022604 | View |