Module
- Number
- 82
- Regulatory Genes
- 2
- Module Genes
- 20
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
bed-1 | Y39B6A.12 | WBGene00012674 | 706 | View | |
2L52.1 | 2L52.1 | WBGene00007063 | 158 |
2L52.1 encodes a protein with sequence similarity to GLI-family zinc-finger transcription factors; deletion mutations in 2L52.1 are reported to be homozygous viable.
|
View |
CLR Predictions
8 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
---|---|---|---|---|
afd-1 | W03F11.6 | WBGene00021009 | View | |
bed-1 | Y39B6A.12 | WBGene00012674 | View | |
C34C6.2 | C34C6.2 | WBGene00007915 | View | |
clec-98 | ZK39.7 | WBGene00013932 | View | |
cul-3 | Y108G3AL.1 | WBGene00000838 |
cul-3 encodes one of six C. elegans cullins; by homology, CUL-3 is predicted to interact with a RING-finger protein to form the catalytic core of an SCF-type E3-ubiquitin ligase complex required for the ubiquitination and degradation of target proteins; in the early embryo, maternal CUL-3 is essential for degradation of MEI-1, a meiosis-specific subunit of the microtubule-severing katanin complex that is active during meiosis but whose degradation is essential for successful mitotic spindle formation and subsequent zygotic cytokinesis; to effect MEI-1 degradation, CUL-3 interacts with MEL-26, a substrate-specific adaptor protein that also binds MEI-1, thus linking MEI-1 with the CUL-3-containing E3 ligase; CUL-3 activity is regulated by cycles of neddylation and deneddylation that are dependent upon activity of the DCN-1, RBX-1, and RFL-1 gene products; cul-3 mRNA is present at all life stages, with highest levels seen in embryos; expression of a cul-3::GFP transcriptional reporter fusion is detected in many somatic tissues, including the pharynx, intestine, hypodermis, and several different muscle types.
|
View |
ech-5 | F56B3.5 | WBGene00001154 | View | |
F11C1.5 | F11C1.5 | WBGene00008694 | View | |
gsk-3 | Y18D10A.5 | WBGene00001746 | View | |
H05C05.1 | H05C05.1 | WBGene00019157 | View | |
H08J11.2 | H08J11.2 | WBGene00019173 | View | |
H24K24.4 | H24K24.4 | WBGene00019241 | View | |
hpk-1 | F20B6.8 | WBGene00001994 |
hpk-1 encodes a predicted dual-specificity protein kinase with distant homology to the vertebrate protein kinase DYRK1A and the Drosophila homolog mini-brain; increased expression of DYRK1A is implicated in the neuropathology of trisomy 21/Down syndrome; RNA interference of hpk-1 does not result in any detectable phenotype; the HPK-1::GFP fusion protein is localized to the nucleus and is expressed in cleavage stage embryos.
|
View |
mab-20 | Y71G12B.20 | WBGene00003111 |
mab-20 encodes the C. elegans Semaphorin-2A ortholog; during development, mab-20 activity is required for proper epidermal morphogenesis and axon guidance; specifically, MAB-20, which functions to prevent ectopic, adhesive cell contacts, is required for ventral enclosure during embryogenesis, normal body morphology, and proper formation of sensory rays in the male tail; co-immunoprecipitation experiments demonstrate that MAB-20 interacts with the PLX-2 receptor and that this interaction is strengthened by LAD-2 which can interact with both proteins independently; a MAB-20::GFP reporter, which localizes to the cell surface, is expressed ubiquitously in embryos beginning at morphogenesis; in larvae and adults, MAB-20::GFP is seen in dividing seam cells, neurons, vulval cells, the distal tip cell in hermaphrodites and in males, is additionally seen in the linker cell, cells in the posterior ganglia, and the 9 R(n) ray precursor cells.
|
View |
rab-33 | F43D9.2 | WBGene00004283 | View | |
W03A5.5 | W03A5.5 | WBGene00020969 | View | |
W05H7.1 | W05H7.1 | WBGene00021044 | View | |
Y111B2A.8 | Y111B2A.8 | WBGene00013732 |
Y111B2A.8 is orthologous to the human gene AMP-ACTIVATED PROTEIN KINASE GAMMA SUBUNIT (PRKAG2; OMIM:602743), which when mutated leads to disease.
|
View |
Y53H1A.1 | Y53H1A.1 | WBGene00013177 | View | |
Y56A3A.31 | Y56A3A.31 | WBGene00013243 | View | |
ZK858.1 | ZK858.1 | WBGene00014115 | View |