Module
- Number
- 81
- Regulatory Genes
- 5
- Module Genes
- 15
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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lin-54 | JC8.6 | WBGene00003037 | 775 | View | |
hmg-4 | T20B12.8 | WBGene00001974 | 489 |
hmg-4 encodes a protein with strong similarity to the highly conserved high mobility group protein SSRP1 (structure-specific DNA recognition protein); by homology, HMG-4 is predicted to be a member of the FACT (facilitates chromatin transcription) complex that functions as a transcription elongation factor; RNAi experiments indicate that hmg-4 is required for locomotion and larval development, and required redundantly with hmg-3, its paralog, for embryonic development.
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tbx-33 | Y66A7A.8 | WBGene00006552 | 239 | View | |
isw-1 | F37A4.8 | WBGene00002169 | 218 |
isw-1 encodes a homolog of the chromatin remodeling ATPase ISW1 that may act downstream of or in parallel to synMuv genes, and upstream of or in parallel to the RTK Ras pathway.
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F37D6.2 | F37D6.2 | WBGene00009508 | 101 | View |
CLR Predictions
20 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C30A5.3 | C30A5.3 | WBGene00016238 | View | |
C32E8.5 | C32E8.5 | WBGene00016323 | View | |
C38C10.2 | C38C10.2 | WBGene00008000 |
C38C10.2 is orthologous to the human gene SOLUTE CARRIER FAMILY 17 (ANION/SUGAR TRANSPORTER), MEMBER 5 (SLC17A5; OMIM:604322), which when mutated leads to disease.
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F40F8.11 | F40F8.11 | WBGene00044916 | View | |
lsm-7 | ZK593.7 | WBGene00003081 | View | |
npp-2 | T01G9.4 | WBGene00003788 |
npp-2 encodes a protein with low similarity to rat nucleoporin Nup75 that affects embryonic viability and has a variety of other defects in RNAi screens including: nuclear morphology, growth, fertility, locomotion, and egg laying; enriched in oocytes.
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patr-1 | F43G6.9 | WBGene00009661 | View | |
rba-1 | K07A1.11 | WBGene00004312 | View | |
rpa-2 | M04F3.1 | WBGene00019767 | View | |
rpb-4 | F43E2.2 | WBGene00018391 | View | |
rpb-8 | F26F4.11 | WBGene00017830 | View | |
rpb-9 | Y97E10AR.5 | WBGene00022400 | View | |
rsp-2 | W02B12.2 | WBGene00004699 | View | |
sna-1 | W02F12.6 | WBGene00020951 |
sna-1 encodes an snRNP-binding protein (SNA-1/SL21p) orthologous to Ascaris SL30p (SL 30kd) and Brugia 13258.m00169, and paralogous to Brugia 14704.m00455; SNA-1 is found in the Sm snRNP SL1, but not in SL2; in snRNP SL1, SNA-1 associates with the SNA-2/SL75p protein, while being replaced by SUT-1/SL26p (a paralog of SNA-1) in snRNP Y; sna-1(RNAi) animals, like sut-1(bk79) mutants, have cold-sensitive sterility, whereas sna-1(RNAi) combined with sut-1(bk79) is synthetically lethal; double sna-1(RNAi) sut-1(RNAi) is lethal; these RNAi data indicate that SNA-1 and SUT-1 are partially redundant, and suggest that snRNP Y (like snRNP SL1) may participate in trans-splicing; SNA-1 can bind SNA-2 even in the absence of RNA.
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ubc-18 | R01H2.6 | WBGene00006713 |
ubc-18 encodes an E2 ubiquitin-conjugating enzyme related to human UBCH7 (OMIM:603731); UBC-18 activity is required for normal growth and reproduction, and UBC-18 functions redundantly with LIN-35/Rb and other class B synthetic multivulval (SynMuv) gene products to regulate pharyngeal morphogenesis during embryonic development; ubc-18 transcripts are detected in the germline, embryos, late larval stages, and adults, suggesting that UBC-18 may function maternally to regulate several aspects of C. elegans development; the substrates of UBC-18 are not yet known.
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