Module
- Number
- 79
- Regulatory Genes
- 3
- Module Genes
- 20
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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C28G1.4 | C28G1.4 | WBGene00016189 | 761 | View | |
nhr-22 | K06A1.4 | WBGene00003621 | 391 | View | |
C43H6.7 | C43H6.7 | WBGene00016620 | 101 | View |
CLR Predictions
24 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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aps-2 | F02E8.3 | WBGene00000157 |
aps-2 encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP2), which mediates endocytosis from the plasma membrane; APS-2 is required for embryonic and larval development and for normal body morphogenesis, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage.
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atg-16.2 | K06A1.5 | WBGene00019427 |
atg-16.2 encodes a divergent ortholog of the autophagic budding yeast protein Atg16p, and of human ATG16L1 (OMIM:610767, associated with Crohn disease) and ATG16L2; ATG-16.2 is paralogous to ATG-16.1; ATG-16.2 has no obvious function in mass RNAi assays.
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chd-3 | T14G8.1 | WBGene00000482 |
chd-3 encodes a PHD-finger SNF2 family member containing a chromo domain and a C-terminal helicase domain that affects Notch-dependent vulval development; expressed in virtually all embryonic cells and in many larval nuclei.
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dao-3 | K07E3.3 | WBGene00000929 |
dao-3 encodes a protein containing tetrahydrofolate dehydrogenase/cyclohydrolase catalytic and NAD(P)-binding domains; by similarity to mammalian enzymes, DAO-3 is predicted to function in one-carbon unit metabolism and thus, in amino acid and nucleotide biosynthesis; dao-3 expression appears to be regulated by daf-2-mediated insulin signaling: microarray experiments suggest that it is upregulated in daf-2 mutant adults, while differential display and Northern analyses suggest that it is down-regulated; a dao-3 promoter gfp fusion is expressed in larvae in the hypodermis and in the nervous system, including tail neurons and phasmids.
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F22B8.7 | F22B8.7 | WBGene00009049 | View | |
F31E8.4 | F31E8.4 | WBGene00017954 | View | |
F48E3.3 | F48E3.3 | WBGene00018604 | View | |
F48F7.6 | F48F7.6 | WBGene00009851 | View | |
F55A4.1 | F55A4.1 | WBGene00018853 | View | |
H28G03.2 | H28G03.2 | WBGene00019250 | View | |
ife-2 | R04A9.4 | WBGene00002060 |
ife-2 encodes a translation initiation factor 4F, cap-binding subunit (eIF-4E); by homology, IFE-2 is predicted to function in cap-dependent mRNA translation initiation; loss of ife-2 activity in adult animals extends lifespan.
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K02B7.3 | K02B7.3 | WBGene00010491 | View | |
K11G12.6 | K11G12.6 | WBGene00019657 | View | |
lnp-1 | C05E11.1 | WBGene00015492 |
lnp-1 encodes a highly conserved protein of unknown function, orthologous to human LUNAPARK/KIAA1715 (OMIM:610236), that is required for normally short body length, normal locomotion, fat content, acetylcholine neurotransmission, localization of RAB-3 and SNB-1, and sensitivity to aldicarb; LNP-1 is expressed in muscles, hypodermal cells, and neurons; within neurons, LNP-1 is localized to cell bodies, neuritic processes and commissures, and requiring UNC-104 for localization outside of cell bodies; LNP-1 is likely to act presynaptically; LNP-1 contains two N-terminal predicted transmembrane sequences, and an atypical zinc finger domain (C2HC2).
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nep-1 | ZK20.6 | WBGene00013926 |
ZK20.6 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; ZK20.6 is closely paralogous to F18A12.8, and orthologous to CG9761 in Drosophila melanogaster; more generally, ZK20.6 falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes).
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pqn-65 | T13H2.4 | WBGene00004148 |
The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
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pyr-1 | D2085.1 | WBGene00004259 |
pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy.
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T12G3.2 | T12G3.2 | WBGene00011738 |
The T12G3.2 gene encodes a protein that may be involved in apoptosis.
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T20F7.6 | T20F7.6 | WBGene00020633 | View | |
Y39G8B.1 | Y39G8B.1 | WBGene00012722 | View |