Module
- Number
- 76
- Regulatory Genes
- 4
- Module Genes
- 20
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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eea-1 | T10G3.5 | WBGene00011696 | 719 |
eea-1 encodes a coiled-coil protein that is the C. elegans ortholog of early endosome antigen 1 (EEA1); eea-1 activity is required for wild-type levels of endocytosis; a fusion protein between EEA-1 FYVE domains and GFP binds endosomal/vacuolar membranes in wild-type worms but not in those lacking vps-34 activity, suggesting that, like its human ortholog, C. elegans EEA-1 binds phosphatidylinositol 3-phosphate (PtdIns 3-P) in vivo; EEA-1 reporter fusion proteins localize to endocytic vesicles.
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D2030.7 | D2030.7 | WBGene00008417 | 494 | View | |
ada-2 | F32A5.1 | WBGene00017967 | 203 | View | |
rab-7 | W03C9.3 | WBGene00004271 | 106 |
rab-7 encodes a Rab GTPase orthologous to the Rab7 GTPases of yeast, Drosophila, and vertebrates; RAB-7 is required for endosome and endosome to lysosome trafficking and thus, for proper yolk protein transport in oocytes and transport of endocytosed materials in coelomoyctes; RAB-7 activity is also required for normal embryogenesis, locomotion, and body morphology; in oocytes stained with anti-RAB-7 antibodies, RAB-7 is expressed in a punctate pattern that is interpreted as an association with organelle membranes; RAB-7 localization, and presumably function, at early and late endosomes is positively regulated by SAND-1, a novel, conserved protein required for early to late endosome maturation and transport.
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CLR Predictions
8 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0495.9 | B0495.9 | WBGene00015208 | View | |
C11D2.7 | C11D2.7 | WBGene00015703 | View | |
C44B7.1 | C44B7.1 | WBGene00016623 | View | |
D2005.3 | D2005.3 | WBGene00008398 | View | |
eif-6 | C47B2.5 | WBGene00001234 |
eif-6 encodes the C. elegans ortholog of vertebrate anti-association factor eIF6 and Saccharomyces cerevisiae Tif6p; EIF-6 is required for lin-4 miRNA-mediated repression of lin-14 and lin-28 mRNA and protein levels and in addition, is required for normal rates of growth and control of cell division in the germ line; eif-6 is expressed ubiquitously (or nearly so) in somatic larval and adult tissues; by orthology to eIF6 and Tif6p, EIF-6 is predicted to be recycled by K10C3.5 and W06E11.4 during maturation of 60S ribosomal subunits, suggesting a link between ribosome assembly and several processes, including miRNA-mediated gene silencing, germline proliferation, and regulation of growth rates; EIF-6 may suppress tumorous growth in the germ line by ensuring robust larval germline proliferation.
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elb-1 | Y41C4A.10 | WBGene00001235 |
elb-1 encodes an Elongin B ortholog required for chromosome condensation and segregation during mitosis and meiotic division II, and also for cell proliferation (probably through degradation of CKI-1); elb-1(RNAi) animals tend to arrest at the second meiotic cell division, with escapers showing many other defects in chromosomal dynamics and cell cycle control such as abnormal pronuclear rotation and cortical protrusion, aberrant chromosomal structures in the intestine, and deficient germ cell proliferation; ELB-1 interacts with ELC-1 and ELC-2 in bacterial two-hybrid experiments.
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F08B4.7 | F08B4.7 | WBGene00017238 | View | |
F19B6.1 | F19B6.1 | WBGene00008948 | View | |
F40F8.1 | F40F8.1 | WBGene00009575 | View | |
lsm-3 | Y62E10A.12 | WBGene00003077 | View | |
pfd-4 | B0035.4 | WBGene00007107 |
pfd-4 encodes a putative prefoldin subunit 4, orthologous to human PFDN4 (OMIM:604898), that is dispensable for viability; PFD-4 is redundant for prefoldin function in C. elegans; pfd-4(gk403) mutants and pfd-4(RNAi) animals, unlike animals undergoing RNAi against most prefoldin subunits, have no obvious phenotypes.
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tag-170 | C05D11.3 | WBGene00006515 |
C05D11.3/tag-170 encodes a thioredoxin domain-containing protein orthologous to human TXNDC9 and ENSG00000145268; in one-cell embryos, C05D11.3/TAG-170 is required for normal nuclear-centrosome rotation, male pronuclear migration, cytokinesis, and mitotic spindles, and for normally long astral microtubules; in early embryos, C05D11.3/TAG-170 is also required for normally rapid microtubule elongation; C05D11.3/tag-170 is expressed in larval and adult neurons and pharynx, and in vulva, with its strongest transcription in adults; like its mammalian ortholog, C05D11.3/TAG-170 protein is both nuclear and cytoplasmic.
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Y105E8A.11 | Y105E8A.11 | WBGene00013671 | View | |
Y38E10A.24 | Y38E10A.24 | WBGene00012602 | View | |
Y39G10AR.20 | Y39G10AR.20 | WBGene00021475 | View | |
Y39G10AR.8 | Y39G10AR.8 | WBGene00021466 | View | |
Y49E10.20 | Y49E10.20 | WBGene00013039 |
Y49E10.20 encodes a ortholog of human CD36 antigen (OMIM:173510, mutated in platelet glycoprotein IV deficiency); Y49E10.20 is needed for cell corpse engulfment in the germline and in the three-fold embryo, and for migration of the anterior arm of the gonad.
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Y53G8AL.2 | Y53G8AL.2 | WBGene00021800 | View | |
Y56A3A.19 | Y56A3A.19 | WBGene00013237 | View | |
Y69A2AR.3 | Y69A2AR.3 | WBGene00022075 | View |