Module
- Number
- 66
- Regulatory Genes
- 5
- Module Genes
- 28
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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mex-6 | AH6.5 | WBGene00003231 | 900 |
mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins.
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pde-1 | T04D3.3 | WBGene00011433 | 246 | View | |
D2030.7 | D2030.7 | WBGene00008417 | 195 | View | |
pos-1 | F52E1.1 | WBGene00004078 | 111 |
pos-1 encodes a CCCH-type zinc-finger protein; during embryogenesis, maternally provided POS-1 is essential for proper fate specification of germ cells, intestine, pharynx, and hypodermis; POS-1's role in cell fate specification is likely as a translational regulator, as POS-1 is required, in posterior blastomeres, for positive regulation of apx-1 mRNA translation and negative regulation of glp-1 mRNA translation via direct binding to the spatial control region (SCR) in the glp-1 mRNA 3' UTR; in regulating mRNA translation, POS-1 interacts with SPN-4, an RNP-type RNA binding protein, that may function to negatively regulate POS-1 activity; pos-1 mRNA is first detected in the gonads of L4 and adult animals, and is present uniformly in oocytes and newly fertilized embryos; during early embryonic divisions, pos-1 mRNA is present at higher levels in germline blastomeres until it disappears following the division of P4; POS-1 protein is first apparent at low levels in 1-cell embryos, with subsequent expression mirroring that of pos-1 mRNA: high levels in germline blastomeres until its disappearance after the P4 division; in the germline blastomeres P1, P2, P3, and P4, POS-1 colocalizes with cytoplasmic and perinuclear P granules.
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zip-4 | Y44E3B.1 | WBGene00021552 | 111 |
zip-4 encodes, by alternative splicing, two isoforms of a putative C/EBP protein, divergently orthologous to human human CEBPA (OMIM:116897, mutated in acute myeloid leukemia), CEBPB (OMIM:189965), CEBPD (OMIM:116898), CEBPE (OMIM:600749, mutated in specific granule deficiency), and CEBPG (OMIM:138972); ZIP-4 is paralogous to CEBP-1; ZIP-4 is weakly expressed in what may be a ubiquitous, constitutive pattern, with higher expression in pharynx, vulva and spermatheca, and somewhat higher expression in the rest of the somatic gonad; ZIP-4 has no obvious function in mass RNAi assays.
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CLR Predictions
303 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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ani-3 | Y43F8C.14 | WBGene00012835 |
ani-3 encodes one of three C. elegans anillins.
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bath-15 | C08C3.2 | WBGene00015590 | View | |
bath-5 | F59H6.11 | WBGene00019141 | View | |
C27D9.1 | C27D9.1 | WBGene00016163 | View | |
C46A5.5 | C46A5.5 | WBGene00016701 | View | |
cpg-4 | C10F3.1 | WBGene00015677 |
cpg-4 encodes a large (782-residue), unfamiliar, putatively secreted protein with a C-terminal low-complexity domain; CPG-4 has 35 potential chondroitin attachment sites, mostly in its C-terminal half, 4 of which have been verified by mass spectrometry; CPG-4 has no obvious function in mass RNAi assays.
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E02H4.6 | E02H4.6 | WBGene00008464 | View | |
F02H6.4 | F02H6.4 | WBGene00008537 | View | |
F22E5.17 | F22E5.17 | WBGene00017712 | View | |
F54D10.7 | F54D10.7 | WBGene00018808 | View | |
fbxa-206 | Y102A5C.1 | WBGene00013610 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
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gei-14 | K01C8.5 | WBGene00001571 |
gei-14 encodes a novel protein that interacts with GEX-3 in yeast two-hybrid assays.
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H27M09.3 | H27M09.3 | WBGene00019247 | View | |
K02F6.7 | K02F6.7 | WBGene00019341 | View | |
M01E11.3 | M01E11.3 | WBGene00019712 | View | |
T01G5.7 | T01G5.7 | WBGene00011342 | View | |
T06D4.1 | T06D4.1 | WBGene00020290 | View | |
T12C9.7 | T12C9.7 | WBGene00020461 | View | |
T24D1.5 | T24D1.5 | WBGene00011988 | View | |
tbx-36 | ZK829.5 | WBGene00006555 | View | |
W06D11.3 | W06D11.3 | WBGene00012301 | View | |
Y48G1A.2 | Y48G1A.2 | WBGene00021658 | View | |
Y49F6C.8 | Y49F6C.8 | WBGene00021730 | View | |
Y54F10AM.11 | Y54F10AM.11 | WBGene00021853 | View | |
Y65B4BL.3 | Y65B4BL.3 | WBGene00022035 | View | |
ZC155.4 | ZC155.4 | WBGene00022532 | View | |
ZK418.8 | ZK418.8 | WBGene00022737 | View | |
ztf-15 | R06C7.9 | WBGene00011066 | View |