Module
- Number
- 65
- Regulatory Genes
- 8
- Module Genes
- 30
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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nhr-40 | T03G6.2 | WBGene00003630 | 384 |
nhr-40 encodes, by alternative splicing and promoters, three isoforms of a nuclear hormone receptor specific to nematodes; NHR-40 is required for normal development of bodywall muscles, and hence for normal movement; both nhr-40 promoters are active in body wall and pharygeal muscle cells, as well as in some (perhaps non-overlapping) neurons of the head and ventral nerve cord; NHR-40 is a divergent ortholog of HNF4, with 17 closely related paralogs in C. elegans belonging to the class 1, subgroup 8 of C. elegans NHRs with the P box sequence CNGCKT; nhr-40 is most strongly transcribed in L2 larvae; nhr-40(RNAi), overexpression of nhr-40 by heat shock, or the nhr-40(ok667) mutation all result in developmentally arrested embryos or larvae, with surviving larvae being smaller, abnormally bulging, and sluggish; nhr-40(RNAi) animals have disorganized epithelial cells and missing body wall muscle cells; nhr-40(ok667) mutants are slow-moving and uncoordinated, frequently reversing direction or going in circles; transgenic expression of nhr-40 cDNA in muscles rescues larval but not embryonic arrest.
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unc-3 | Y16B4A.1 | WBGene00006743 | 289 |
The unc-3 gene encodes a protein with homology to immunoglobulin (Ig) domain-containing transcription factors such as OLF-1 or SU(H).
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unc-42 | F58E6.10 | WBGene00006778 | 247 |
unc-42 encodes a paired-like homeodomain protein of the Q50 class; UNC-42 is required to specify the fate of ASH sensory neurons, AVA, AVD, and AVE interneurons, and a subset of motor neurons; unc-42 mutants fail to express cell-surface receptors required for differentiated neuronal function (sra-6, srb-6, glr-1, glr-5, and glr-6); UNC-42 is also required for AVKR and HSNL growth cones to follow the PVPR and PVQL pioneer axons, for axonal outgrowth in the backward command interneurons AVA, AVD, and AVE, and for inhibition of ectopic FMRFamide-positive and GABAergic axons; unc-42 mutants are defective in mechanosensation, backward motion, and regulation of egg-laying.
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K11D2.4 | K11D2.4 | WBGene00010770 | 164 | View | |
nhr-143 | F59E11.11 | WBGene00019116 | 160 | View | |
ztf-2 | F13G3.1 | WBGene00008762 | 144 | View | |
gpa-2 | F38E1.5 | WBGene00001664 | 141 |
gpa-2 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that is involved in dauer formation and chemotaxis to water-soluble odorants; it is expressed in the phasmid neurons PHA and PHB, three pharyngeal neurons, one interneuron, three pairs of head neurons, and the anal sphincter muscle.
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gpa-14 | B0207.3 | WBGene00001676 | 120 |
gpa-14 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; gpa-14 is expressed in ASI, ASJ, ASH, ASK, ADE, PHA, PHB ALA, AVA, CAN, DVA, PVQ, RIA, and in vulval muscle, and also exhibits faint expression in the vulval hypodermis.
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CLR Predictions
107 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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ace-3 | Y48B6A.8 | WBGene00000037 |
ace-3 encodes one of four C. elegans acetylcholinesterases (AChE); ACE-3 represents ~5% of the total AChE activity in C. elegans and in vitro, hydrolyzes acetylthio-, butyrylthio-, and propionylthiocholine substrates with equal efficiency; although loss-of-function mutations in ace-3 result in no obvious defects, animals doubly mutant with ace-1 or ace-2 have slight defects in backward locomotion and animals triply mutant for ace-1, -2, and -3 arrest as unhatched, yet fully developed, embryos; ace-3 is the downstream gene in an operon with a fourth AChE-encoding gene, ace-4, and transcriptional reporter fusions with ace-4 upstream sequences direct expression in pharyngeal muscles pm3, 4, 5, and 7, the two CAN (canal associated neuron) cells, midbody dorsal body wall muscles in larvae, and several neurons in the head and anal ganglion
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C35E7.11 | C35E7.11 | WBGene00016463 | View | |
che-12 | B0024.8 | WBGene00000491 |
che-12 encodes a conserved protein that contains at least seven predicted HEAT repeats; CHE-12 activity is required continuously in sensory neurons for formation of distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis to a subset of attractants, including sodium chloride; a che-12::gfp promoter fusion is expressed in the two phasmid neurons and the subset of amphid neurons that contain relatively simple cilia; a CHE-12::GFP protein localizes to cilia in a manner suggesting that it requires intraflagellar transport for proper localization, but is unlikely to be a core IFT particle component; che-12 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor.
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dpy-20 | T22B3.1 | WBGene00001079 |
dpy-20 encodes a BED zinc finger protein, with no known homologs outside of nematodes, that is required for normal body morphology.
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E04F6.10 | E04F6.10 | WBGene00017129 | View | |
F02A9.1 | F02A9.1 | WBGene00008513 | View | |
F08B4.4 | F08B4.4 | WBGene00017236 | View | |
F32B6.11 | F32B6.11 | WBGene00009325 |
F32B6.11 encodes a small (140-residue) protein, with a single putative transmembrane domain, that is orthologous to Drosophila INAF-B; sequence conservation of INAF-B and its metazoan homologs is highest in a 32-residue motif corresponding to its predicted transmembrane domain; by orthology with INAF-B, F32B6.11 is expected to be an auxillary subunit of TRP channels such as OSM-9, and F32B6.11 expression is enriched in motor neurons; however, F32B6.11 has no obvious function in mass RNAi assays.
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F35C5.11 | F35C5.11 | WBGene00009399 | View | |
F45E4.7 | F45E4.7 | WBGene00018472 | View | |
F47B10.8 | F47B10.8 | WBGene00009819 | View | |
F49H12.3 | F49H12.3 | WBGene00018654 | View | |
F59B8.1 | F59B8.1 | WBGene00010316 | View | |
gpa-14 | B0207.3 | WBGene00001676 |
gpa-14 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; gpa-14 is expressed in ASI, ASJ, ASH, ASK, ADE, PHA, PHB ALA, AVA, CAN, DVA, PVQ, RIA, and in vulval muscle, and also exhibits faint expression in the vulval hypodermis.
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hst-3.1 | F40H3.5 | WBGene00002030 | View | |
ifta-2 | T28F3.6 | WBGene00012132 |
ifta-2 encodes a ciliary protein, orthologous to human RABL5, that is required for normally short life span and dauer formation; IFTA-2 is expressed in amphid, labial, and phasmid ciliated sensory neurons; intracellularly, IFTA-2 resides in the bases and axonemes of cilia, colocalizing with DAF-2 and AGE-1; IFTA-2 may be either a cargo or a cargo-docking component of intraflagellar transport (IFT) by the IFT-B complex; ciliary basal localization of IFTA-2 is abolished by a T42N mutation predicted to lock ITFA-2 into an inactive, GDP-bound conformation; ifta-2(tm1724) mutants have abnormally long lifespans and constitutive dauer formation, perhaps because IFTA-2 regulates DAF-2 signalling from ciliated sensory neurons; IFTA-2 is not required for cilium assembly or IFT, nor is it required for chemosensation or osmosensation; the ciliary localization of IFTA-2 is conserved in RABL5; via an X-box in its promoter, ifta-2 is a candidate for direct regulation by DAF-19.
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npr-2 | T05A1.1 | WBGene00003808 | View | |
osm-10 | T20H4.1 | WBGene00003890 |
osm-10 encodes a novel protein conserved amongst several Caenorhabditis species; osm-10 activity is required for normal osmosensory signaling in the ASH sensory neuron; in regulating ASH-mediated osmosensation, osm-10 interacts genetically with eos-1 and eos-2; OSM-10 is expressed in the ASH, ASI, PHA, and PHB sensory neurons beginning just prior to hatching and continuing through larval and adult stages; OSM-10 localizes to cell bodies, sensory processes, and axons.
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ssu-2 | Y67A10A.6 | WBGene00013455 | View | |
T03G11.3 | T03G11.3 | WBGene00020196 | View | |
T12B3.1 | T12B3.1 | WBGene00020444 | View | |
T19D7.5 | T19D7.5 | WBGene00020573 | View | |
T21B4.4 | T21B4.4 | WBGene00011878 | View | |
T26A8.2 | T26A8.2 | WBGene00020825 | View | |
tyra-2 | F01E11.5 | WBGene00017157 | View | |
ubc-17 | B0403.2 | WBGene00006712 | View | |
unc-24 | F57H12.2 | WBGene00006761 |
unc-24 encodes a protein that contains a stomatin-like domain and a lipid transfer domain; unc-24 activity is essential for normal locomotion and for wild-type sensitivity to lipid-soluble volatile anesthetics; unc-24 is genetically epistatic to unc-79 and to unc-1, which encodes an additional stomatin whose stability and localization to the nerve ring are dependent upon UNC-24; unc-24 is expressed in the touch receptor neurons as well as neurons in the ventral cord.
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Y73F8A.5 | Y73F8A.5 | WBGene00013518 | View | |
ZC443.2 | ZC443.2 | WBGene00013897 | View | |
ZC449.2 | ZC449.2 | WBGene00022612 | View |