Module
- Number
- 63
- Regulatory Genes
- 5
- Module Genes
- 17
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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ceh-40 | F17A2.5 | WBGene00000461 | 621 |
ceh-40 encodes one of two C. elegans homeodomain proteins homologous to Extradenticle (Exd/Pbx); ceh-40 genetically interacts with ceh-20 and unc-62 during embryonic development: while loss of ceh-40 activity alone results in no significant embryonic lethality, loss of ceh-40 and ceh-20, or ceh-40, ceh-20, and unc-62, results in incompletely penetrant embryonic lethality.
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C12D12.5 | C12D12.5 | WBGene00015716 | 278 | View | |
nhr-2 | C32F10.6 | WBGene00003601 | 236 |
nhr-2 encodes a member of the nuclear hormone receptor family that is required for embryonic viability and morphogenesis; expressed during embryogenesis.
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F37B4.10 | F37B4.10 | WBGene00018140 | 193 | View | |
ran-1 | K01G5.4 | WBGene00004302 | 120 |
ran-1 encodes the C. elegans Ran GTPase ortholog; ran-1 activity is essential for proper mitotic spindle formation, effective connection between centrosomes and the male pronucleus, nuclear envelope assembly after cell division, and oocyte meiotic maturation; in regulating nuclear envelope dynamics, ran-1 appears to function upstream of MEL-28 by regulating its localization to the nuclear periphery; in regulating oocyte meiotic maturation, RAN-1 interacts with VAB-1 MSP/Eph and regulates its localization to endocytic-recycling vesicles in the absence of the major sperm protein (MSP)/sperm; in dissected gonads and oocytes, RAN-1 staining is detected at the cortex.
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CLR Predictions
12 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0238.11 | B0238.11 | WBGene00015075 | View | |
C47E8.4 | C47E8.4 | WBGene00008143 |
C47E8.4 encodes a conserved protein that is a member of the FAM50A/XAP5 family of proteins; loss of C47E8.4 activity via RNAi results in some embryonic and larval lethality as well as animals that are thin and paralyzed; in age-1 long-lived mutants, loss of C47E8.4 results in a small, but reproducible, reduction in lifespan; the Arabidopsis thaliana XAP5 ortholog, XCT, is a broadly expressed nuclear protein required for proper environmental (light) regulation of the circadian clock and photomorphogenesis.
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cyn-13 | Y116A8C.34 | WBGene00000889 |
cyn-13 encodes a predicted cyclophilin that can function as a nuclease in vitro; functions to regulate DNA degradation and cell death in a genetic pathway with wah-1, cps-6, crn-1, crn-4, crn-5 and these proteins are believed to form a complex in vivo.
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gut-2 | T10G3.6 | WBGene00001808 |
gut-2 encodes a member of the Sm protein family with highest similarity to human U6 snRNA-associated Sm-like protein, LSm2, that affects embryonic viability.
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hrp-1 | F42A6.7 | WBGene00001999 |
The hrp-1 gene encodes a homolog of the human DRPLA gene (OMIM:125370), which when mutated leads to dentatorubral-pallidoluysian atrophy or to Haw River syndrome (OMIM:140340).
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hrpf-1 | W02D3.11 | WBGene00020936 |
W02D3.11 encodes, by alternative splicing, two protein isoforms orthologous to human hnRNP F and hnRNP H proteins, which activate alternative mRNA splicing in neurons; W02D3.11A-B proteins localize to nuclear speckles thought to represent foci of pre-mRNA; with EXC-7 and UNC-75, W02D3.11A-B may act as pre-mRNA splicing factors.
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lin-53 | K07A1.12 | WBGene00003036 | View | |
rpb-6 | C06A1.5 | WBGene00007355 | View | |
rsp-4 | EEED8.7 | WBGene00004701 | View | |
rsp-6 | C33H5.12 | WBGene00004703 | View | |
T06D8.7 | T06D8.7 | WBGene00011528 | View | |
T20B12.7 | T20B12.7 | WBGene00020604 | View | |
tag-135 | D1054.15 | WBGene00006481 | View | |
top-2 | K12D12.1 | WBGene00010785 | View | |
unc-37 | W02D3.9 | WBGene00006773 |
The unc-37 gene encodes a transducin-like WD-repeat protein homologous to Drosophila GROUCHO that genetically interacts with components of the transcriptional Mediator complex.
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Y110A7A.4 | Y110A7A.4 | WBGene00022455 | View | |
Y59A8B.10 | Y59A8B.10 | WBGene00013347 | View |