Module
- Number
- 60
- Regulatory Genes
- 4
- Module Genes
- 27
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
mex-6 | AH6.5 | WBGene00003231 | 822 |
mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins.
|
View |
D1046.2 | D1046.2 | WBGene00008363 | 262 | View | |
C27A12.2 | C27A12.2 | WBGene00016154 | 127 | View | |
cid-1 | K10D2.3 | WBGene00019629 | 124 |
cid-1 (also known as pup-1) encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, orthologous to human ZCCHC6 and ZCCHC11, and paralogous to PUP-2; CID-1 prevents larvae from growing to adulthood in media containing hydroxyurea (HU, a drug that stalls replication forks) and represses HSP-4 expression; CID-1 is required for gonadogenesis, embryonic and vulval development, normally rapid growth, and normally short lifespan; CID-1, like HSP-4, is expressed in postmitotic intestinal cells; by orthology with Cid1p in fission yeast, CID-1 is predicted to act in a DNA synthesis-to-mitosis checkpoint; in cid-1(rf35::Tc4) mutants or cid-1(RNAi) animals grow from L1 larvae to adulthood despite the presence of HU, are abnormally resistant to lethal heat shock, overexpress hsp-4::GFP, have protruding vulvae, have abnormally short and thick gonads with fewer germ cells than normal, produce disorganized embryos, grow slowly, and have abnormally long lifespans; CID-1 and its eukaryotic homologs are distantly related to the GLD-2 family of poly(A) polymerases.
|
View |
CLR Predictions
38 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
---|---|---|---|---|
aat-9 | Y53H1C.1 | WBGene00000010 |
aat-9 encodes an amino acid transporter catalytic subunit; AAT-9 lacks the conserved cysteine residue proposed to be essential for association with a glycoprotein subunit, and when expressed alone in Xenopus ooctyes, AAT-9 can localize to the cell surface and function as an aromatic amino acid exchanger that displays substrate-activated anion conductance; nevertheless, AAT-9 activity is enhanced by co-expression with the ATG-1 and ATG-2 glycoprotein subunits; an aat-9::gfp promoter fusion directs expression in anterior neurons, including some chemosensory neurons, as well as in some anterior body wall muscles.
|
View |
C06H2.3 | C06H2.3 | WBGene00007387 | View | |
C09G5.2 | C09G5.2 | WBGene00007488 |
C09G5.2 encodes an ortholog of S. cerevisiae DPH2/YKL191W and human DPH2L2 (OMIM:603456); C09G5.2 is a putative protein component of diphtamide synthesis; C09G5.2 has no obvious function in mass RNAi assays.
|
View |
C34E10.8 | C34E10.8 | WBGene00016409 | View | |
C50E3.5 | C50E3.5 | WBGene00016816 | View | |
cup-5 | R13A5.1 | WBGene00000846 |
The cup-5 gene encodes an ortholog of the human mucolipin-1 gene, and is required for the normal, negative regulation of endocytotic uptake of markers from pseudocoelomic fluid.
|
View |
F29C12.3 | F29C12.3 | WBGene00009245 | View | |
F53H1.3 | F53H1.3 | WBGene00018777 | View | |
figl-1 | F32D1.1 | WBGene00017981 |
F32D1.1 encodes an homolog of human SPASTIN (OMIM:604277, mutated in spastic paraplegia), FIDGETIN (OMIM:605295, mutated in fidget mice), and FIDGETIN-LIKE-1, and of Drosophila SPASTIN; recombinant F32D1.1 protein has N-ethylmaleimide-sensitive ATPase activity in vitro, which is strongly dependent on the C368 residue immediately C-terminal to its Walker A motif; F32D1.1 is required for persistence of the germline in RNAi assays.
|
View |
H20J04.2 | H20J04.2 | WBGene00019217 | View | |
H25P19.1 | H25P19.1 | WBGene00019244 | View | |
ing-3 | Y51H1A.4 | WBGene00013095 |
Y51H1A.4 is orthologous to the human gene P33ING1B (ING1; OMIM:601566), which when mutated leads to disease.
|
View |
jmjd-2 | Y48B6A.11 | WBGene00012982 | View | |
mtm-9 | Y39H10A.3 | WBGene00003479 |
mtm-9 encodes a myotubularin orthologous to human MTMR9 (OMIM:606260) that affects phosphoinositide 3-phosphate localization, and whose mutation blocks endocytosis by the coelomocytes of C. elegans; MTM-9 is believed to function as part of a complex with MTM-6A and it is predominantly localized to the coelomocyte cytoplasm, with some localization to the membrane.
|
View |
rad-54 | W06D4.6 | WBGene00004298 |
rad-54 is orthologous to the human gene RAD54 (RAD54L; OMIM:603615), which when mutated leads to disease.
|
View |
T22C1.6 | T22C1.6 | WBGene00011917 | View | |
W03F9.2 | W03F9.2 | WBGene00021000 | View | |
W04A4.5 | W04A4.5 | WBGene00012234 | View | |
Y104H12D.2 | Y104H12D.2 | WBGene00022426 | View | |
Y18D10A.1 | Y18D10A.1 | WBGene00012474 | View | |
Y41D4A.6 | Y41D4A.6 | WBGene00021508 | View | |
Y48E1C.1 | Y48E1C.1 | WBGene00013014 | View | |
Y51A2D.7 | Y51A2D.7 | WBGene00013075 | View | |
Y57A10A.25 | Y57A10A.25 | WBGene00013265 | View | |
Y75B8A.16 | Y75B8A.16 | WBGene00013551 | View | |
Y75B8A.25 | Y75B8A.25 | WBGene00013558 | View | |
ZC513.5 | ZC513.5 | WBGene00022629 | View |