Module
- Number
- 58
- Regulatory Genes
- 3
- Module Genes
- 21
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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sex-1 | F44A6.2 | WBGene00004786 | 915 |
sex-1 encodes a DNA-binding protein that is a member of the nuclear hormone receptor superfamily of transcriptional regulators; during embryonic development, SEX-1 functions as an X chromosome signal element that transmits the primary sex-determination signal by negatively regulating transcription of xol-1, a gene whose expression levels correlate with hermaphrodite or male development (low xol-1 levels result in hermaphrodite development, high xol-1, in that of males); in vivo, SEX-1 can associate with extrachromosomal arrays containing the xol-1 promoter, indicating that SEX-1's affect on xol-1 transcription is likely to be direct; SEX-1 localizes to nuclei from oogenesis through mid-embryogenesis, with highest levels of expression visible during early gastrulation (28-100-cell-stage); the SEX-1 expression pattern appears to be similar in hermaphrodites and males.
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eya-1 | C49A1.4 | WBGene00001377 | 390 |
eya-1 encodes a protein orthologous to the Eyes absent/Eya Drosophila protein which is involved in eye development and has protein tyrosine phosphatase ; RNA interference and mutant studies indicate that eya-1 is involved in embryonic and larval tissue morphogenesis as well as larval viability; eya-1 mutants show increased embryonic cell deaths due to activation of the cell death pathway; eya-1 functions redundantly with vab-3/eyeless to control larval viability and anterior body morphogenesis; GFP studies show that eya-1 is expressed in a subset of nuclei during embryonic morphogenesis; the human genes EYA1 and EYA4, when mutated, lead to disease syndromes.
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hnd-1 | C44C10.8 | WBGene00001981 | 174 |
hnd-1 encodes a Hand bHLH transcription factor required for normal viability, gonadogenesis, and posterior body morphology; HND-1 is required for the formation of both somatic gonadal precursors and primordial germ cells, but not for later gonadogenesis; HND-1 is expressed embryogenesis in embryonic mesodermal precursor cells generating (mostly) body wall muscle, in somatic gonad precursor cells, and in some unidentified head cells; the primary defect in hnd-1 mutants may be, nonautonomously, in mesodermal precursor cells; somatic gonad precursor cells are normally generated in hnd-1 mutants, but not maintained.
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CLR Predictions
42 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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dlx-1 | Y80D3A.3 | WBGene00013583 | View | |
F36H5.4 | F36H5.4 | WBGene00018103 | View | |
F36H5.8 | F36H5.8 | WBGene00018106 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
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F42G2.6 | F42G2.6 | WBGene00018355 | View | |
F45D11.5 | F45D11.5 | WBGene00018452 | View | |
F47D12.5 | F47D12.5 | WBGene00018561 | View | |
fbxb-10 | T08E11.6 | WBGene00020362 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
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fbxb-11 | F45C12.5 | WBGene00018436 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
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fbxb-13 | C08F1.3 | WBGene00015607 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
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fbxb-66 | Y40B1B.3 | WBGene00044066 | View | |
fbxb-8 | F49B2.1 | WBGene00009861 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
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fbxb-85 | R17.1 | WBGene00011267 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
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fbxb-88 | C33F10.13 | WBGene00016359 | View | |
fbxc-19 | T08E11.5 | WBGene00020361 | View | |
fbxc-39 | F45D11.10 | WBGene00018456 | View | |
M03B6.4 | M03B6.4 | WBGene00010836 | View | |
sdz-31 | T11A5.5 | WBGene00011704 | View | |
T14G8.2 | T14G8.2 | WBGene00011770 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
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T20D4.19 | T20D4.19 | WBGene00020624 | View | |
Y71F9AL.7 | Y71F9AL.7 | WBGene00022112 | View | |
zeel-1 | Y39G10AR.5 | WBGene00021463 |
zeel-1 encodes a large (917-residue) putative membrane protein, probably enriched in male soma, that is required for compatibility between the Bristol N2 and Hawaiian CB4856 strains of C. elegans; ZEEL-1 has a ~200-residue N-terminal region with six predicted transmembrane sequences, followed by a ~700-residue C-terminal region with normal (globular) amino acid composition but with no known protein motifs; the globular domain of ZEEL-1 has at least 18 C. elegans paralogs, and is divergently related to ZYG-11 and its metazoan orthologs; ZEEL-1 is required zygotically for the viability of embryos also carrying a paternal peel-1(CB4856) allele; a naturally occurring zeel-1 deletion in CB4856, a Hawaiian C. elegans strain, is zygotically lethal with paternal peel-1(Hawaii), and thus is genetically incompatible with C. elegans N2 Bristol; zeel-1 alleles from N2 and CB4856 are embedded in haplotypes that are both present in C. elegans wild populations, and are likely to comprise a balanced polymorphism under some (unknown) form of continuing positive selection; zeel-1 transcripts are enriched in male somatic tissues; other than lethality with paternal peel-1(Hawaii), zeel-1 deletion mutants have no known phenotype, and ZEEL-1 has no obvious function in mass RNAi assays.
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