Module
- Number
- 49
- Regulatory Genes
- 3
- Module Genes
- 33
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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F57C9.4 | F57C9.4 | WBGene00019011 | 754 | View | |
lin-54 | JC8.6 | WBGene00003037 | 362 | View | |
ZK337.2 | ZK337.2 | WBGene00013970 | 256 | View |
CLR Predictions
10 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0238.12 | B0238.12 | WBGene00015076 |
B0238.12 encodes a putative secreted TIL-domain protease inhibitor paralogous to SWM-1, ISL-1, and the products of 11 other C. elegans genes; B0238.12 and its relatives are collectively similar to other TIL-domain protease inhibitors from nematodes, insects, and vertebrates; B0238.12 has no obvious function in mass RNAi assays.
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B0310.1 | B0310.1 | WBGene00015137 |
B0310.1 encodes a nematode-specific transmembrane protein; loss of B0310.1 activity via RNAi results in reduced fat content in wild-type and tub-1 mutant animals, suggesting that B0301.1 plays a role in lipid metabolism.
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B0399.1 | B0399.1 | WBGene00007176 | View | |
C05C9.1 | C05C9.1 | WBGene00007325 | View | |
cgt-1 | T06C12.10 | WBGene00011517 | View | |
ctn-1 | Y23H5A.5 | WBGene00000832 |
ctn-1 encodes a protein that belongs to the alpha-catulin family of catenin-like proteins; the precise function of ctn-1 is not yet known; the CTN-1 promoter-GFP fusion protein is expressed in body wall, vulval and anal muscle tissues.
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egl-8 | B0348.4 | WBGene00001177 |
egl-8 encodes a phospholipase C beta homolog that affects pharyngeal pumping, defecation, and activity levels; it is genetically downstream of egl-30 with respect to aldicarb-induced paralysis, and is expressed in most or all neurons, with the strongest staining in the head and tail ganglia, and in the intestine.
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F16F9.1 | F16F9.1 | WBGene00017513 | View | |
F16H11.1 | F16H11.1 | WBGene00017530 | View | |
F28E10.1 | F28E10.1 | WBGene00017900 | View | |
F32D8.10 | F32D8.10 | WBGene00009333 | View | |
F54E4.3 | F54E4.3 | WBGene00010059 | View | |
gpa-12 | F18G5.3 | WBGene00001674 |
gpa-12 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in the pharynx and in the hypodermis.
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H08M01.2 | H08M01.2 | WBGene00010374 | View | |
H11E01.3 | H11E01.3 | WBGene00019188 | View | |
lev-1 | F09E8.7 | WBGene00002974 |
lev-1 encodes a non-alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, regulation of egg-laying behavior, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3; a LEV-1::GFP fusion protein is expressed in all body wall muscle cells and a subset of ventral cord motor neurons.
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mef-2 | W10D5.1 | WBGene00003182 |
mef-2 encodes a transcription factor that is the sole C. elegans member of the MEF2 subgroup of MADS box transcription factors; loss of mef-2 activity does not result in a strong visible phenotype, although mef-2 mutant adults are slightly dumpy (Dpy); in vitro, MEF-2 is able to bind a consensus MEF2 DNA binding site and interact with the class II histone deacetylase encoded by C10E2.3 (hda-4/hda-7); mef-2 mRNA is detected at all stages of development and expression of mef-2 reporter gene fusions begins in neurons during late embryogenesis and continues in all tissues throughout postembryonic development; mef-2 mutations do not appear to interact with mutations in other myogenic factors such as hlh-1, hlh-8, pha-1, and unc-120.
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nhr-1 | R09G11.2 | WBGene00003600 |
nhr-1 encodes a member of the nuclear receptor superfamily; phylogenetic analyses indicate that NHR-1 is a divergent nuclear receptor that likely arose from expansion and diversification of the HNF4 (NR2A) subgroup in C. elegans; nhr-1 reporter gene expression is detected in hypodermal cells from the 3-fold stage of embryogenesis until adulthood, but as loss of nhr-1 activity via mutation or large-scale RNAi screens does not result in any obvious abnormalities, the precise role of NHR-1 in C. elegans development and/or behavior is not yet known.
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nhr-142 | F44E7.8 | WBGene00018430 | View | |
pde-1 | T04D3.3 | WBGene00011433 | View | |
rgs-2 | F16H9.1 | WBGene00004345 |
rgs-2 encodes a regulator of G protein signaling; by homology, RGS-2 is predicted to function as a GTPase-activating protein for heterotrimeric G-protein alpha-subunits, and in vitro RGS-2 can stimulate the GTPase activity of purified GOA-1; in vivo, rgs-2 appears to function redundantly with rgs-1 to regulate egg-laying behavior when animals are refed following starvation; rgs-2 is expressed in pharyngeal and uterine muscles and in a subset of neurons, including neurons in the ventral cord and head- and tail-ganglia.
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sng-1 | T08A9.3 | WBGene00004912 |
sng-1 encodes the C. elegans synaptogyrin ortholog, a vertebrate integral membrane synaptic vesicle protein; loss-of-function mutations in sng-1 result in no obvious defects in synaptogenesis or neuronal activity, suggesting that SNG-1 is likely required for more subtle neuronal functions; SNG-1::GFP reporters are expressed throughout the nervous system in neurons in the dorsal and ventral nerve cords, as well as the anterior nerve ring; SNG-1 colocalizes with the synaptic vesicle component SNT-1.
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T04F8.3 | T04F8.3 | WBGene00011442 | View | |
T10H10.2 | T10H10.2 | WBGene00020426 | View | |
T20D4.6 | T20D4.6 | WBGene00020612 | View | |
Y105E8A.13 | Y105E8A.13 | WBGene00013673 | View | |
Y41C4A.12 | Y41C4A.12 | WBGene00012758 | View | |
Y43F8C.11 | Y43F8C.11 | WBGene00012833 | View | |
Y71H2AM.10 | Y71H2AM.10 | WBGene00022175 | View | |
Y75B8A.11 | Y75B8A.11 | WBGene00013548 | View | |
Y75B8A.3 | Y75B8A.3 | WBGene00013540 | View | |
zag-1 | F28F9.1 | WBGene00006970 |
zag-1 encodes a homeodomain protein of the ZFH class which consists of a homeodomain flanked by two clusters of C2H2-type zinc fingers and is related to transcriptional repressors encoded by Drosophila zfh-1 and the vertebrate ZEB genes; ZAG-1 is required for locomotion, for neuronal differentiation, and for proper axonal branching and fasciculation; from late embryogenesis through adult stages of development, ZAG-1 is expressed dynamically in head and tail neurons and in the intestinal and anal depressor muscles.
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ZC449.4 | ZC449.4 | WBGene00022614 | View |