Module
- Number
- 46
- Regulatory Genes
- 6
- Module Genes
- 34
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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F53H10.2 | F53H10.2 | WBGene00010012 | 872 | View | |
lin-22 | Y54G2A.1 | WBGene00003008 | 150 |
lin-22 encodes a basic helix-loop-helix (bHLH)-containing protein that is homologous to the Drosophila hairy/Enhancer of split transcriptional repressors; during postembryonic development, lin-22 activity is required for patterning of midbody epidermal and neuronal lineages.
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ceh-20 | F31E3.1 | WBGene00000443 | 136 |
ceh-20 encodes the C. elegans ortholog of the homeodomain co-factor Extradenticle (Exd/Pbx); together with ceh-40 and unc-62, ceh-20 activity is required for embryonic viability; ceh-20 is also required as a cofactor for LIN-39- and MAB-5- dependent postembryonic mesoderm patterning; in addition, ceh-20 is required for regulating post-embryonic migrations of the Q neuroblast descendants and for regulating vulval development; a CEH-20::GFP fusion protein is expressed in embryos and postembryonically in many cell types including the Q, P, and V cells and their descendants; CEH-20 localizes to the nucleus.
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C49C8.5 | C49C8.5 | WBGene00016769 | 120 | View | |
Y43C5A.2 | Y43C5A.2 | WBGene00012782 | 106 | View | |
R06B9.3 | R06B9.3 | WBGene00011054 | 105 | View |
CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C14C6.5 | C14C6.5 | WBGene00015759 | View | |
C15C8.3 | C15C8.3 | WBGene00007605 | View | |
C15H9.9 | C15H9.9 | WBGene00015803 | View | |
C46G7.2 | C46G7.2 | WBGene00016722 | View | |
clec-1 | F25B4.9 | WBGene00017772 | View | |
col-103 | F56B3.1 | WBGene00000677 | View | |
col-98 | F14F7.1 | WBGene00000673 | View | |
cpn-3 | F28H1.2 | WBGene00000779 |
cpn-3 encodes a calponin homolog, most closely related to its paralog CPN-4 in C. elegans; CPN-3 is more similar to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25 than to calponin per se.
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cpr-5 | W07B8.5 | WBGene00000785 |
cpr-5 encodes a cysteine protease.
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elo-5 | F41H10.7 | WBGene00001243 |
The elo-5 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; ELO-5 is required for normally rapid growth and for normal fatty acid composition.
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F13D12.6 | F13D12.6 | WBGene00008741 |
F13D12.6 is orthologous to the human gene SIMILAR TO PROTECTIVE PROTEIN FOR BETA-GALACTOSIDASE (GALACTOSIALIDOSIS) (PPGB; OMIM:256540), which when mutated leads to disease.
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F19C7.1 | F19C7.1 | WBGene00017591 | View | |
F28A12.4 | F28A12.4 | WBGene00017881 | View | |
F28H7.3 | F28H7.3 | WBGene00009237 | View | |
F52E1.14 | F52E1.14 | WBGene00044696 | View | |
F54D5.4 | F54D5.4 | WBGene00010050 | View | |
F59B1.2 | F59B1.2 | WBGene00019097 | View | |
fat-6 | VZK822L.1 | WBGene00001398 |
fat-6 encodes a delta-9 fatty acid desaturase that is predicted to be mitochondrial.
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lec-10 | W01A11.4 | WBGene00002273 |
lec-10 encodes a galectin, a soluble galactose-binding lectin; recombinant lec-10 can bind to sugar in an in vitro assay.
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lec-2 | F52H3.7 | WBGene00002265 |
lec-2 encodes a 'tandem repeat' type galectin (beta-galactosyl-binding lectin) containing two, tandemly arranged carbohydrate recognition domains; by homology, LEC-2 may play roles in cell adhesion and aggregation, proliferation, or programmed cell death, but as loss of lec-2 activity via large-scale RNAi screens does not result in obvious abnormalities, the precise role of LEC-2 in C. elegans development and/or behavior is not yet known.
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lec-8 | R07B1.10 | WBGene00002271 | View | |
LLC1.2 | LLC1.2 | WBGene00010793 | View | |
lys-4 | F58B3.1 | WBGene00003093 | View | |
lys-7 | C02A12.4 | WBGene00003096 |
lys-7 encodes an enzyme homologous to an antimicrobial lysozyme encoded by the LYS4 gene of the protozoan parasite Entamoeba histolytica; by homology, LYS-7 is predicted to function as an antimicrobial enzyme that hydrolyzes the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of prokaryotic cell walls; in C. elegans, lys-7 expression is significantly upregulated in response to infection with the Gram-negative bacterium Serratia marcescens, indicating that LYS-7 likely plays a role in the innate immune response; constitutive expression of lys-7 mRNA is detected in the intestine and the intestinal valve cells.
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lys-8 | C17G10.5 | WBGene00003097 |
lys-8 encodes a putative lysozyme required for normal longevity, probably because it prevents killing of C. elegans by bacteria infecting its gut; LYS-8 is expressed in intestine up to the terminal bulb of the pharynx, as well as in g1 and g2 pharyngeal gland cells; LYS-8 expression is induced by infection with Serratia marcescens, Pseudomonas aeruginosa, or (weakly) by Microbacterium nematophilum; LYS-8 expression is promoted by DBL-1, TIR-1 and NSY-1; lys-8 transcripts are increased by both DBL-1 and SMA-2 (though not strongly affected by LON-2), perhaps reflecting a general role of the DBL-1 signalling pathway in activating intestinal genes and susceptibility of dbl-1 mutants to infection; lys-8 transcripts are repressed by DAF-2 (and thus presumably increased by DAF-16), and lys-8(RNAi) animals display reduced lifespan; induction of LSY-8 by any of three different Gram-negative bacteria (E. coli, S. marcescens, or P. aeruginosa) requires DAF-16, DBL-1, and NSY-1; LSY-8 and its paralogs (LYS-1 to -7 and LYS-10) are more similar to lysozymes from the amoeboid protozoon Entamoeba histolytica than to more familiar ones from vertebrates.
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R13H4.2 | R13H4.2 | WBGene00014826 | View | |
spp-18 | F27C8.4 | WBGene00005003 | View | |
tnt-2 | F53A9.10 | WBGene00006587 | View | |
ttr-2 | K03H1.4 | WBGene00010539 |
K03H1.4 encodes a protein containing a predicted signal sequence followed by a transthyretin-like domain; the product of K03H1.4 belongs to a family of apparently nematode-specific proteins whose function is not yet known.
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ttr-46 | T07C12.7 | WBGene00011571 | View | |
unc-15 | F07A5.7 | WBGene00006754 |
The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants.
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unc-87 | F08B6.4 | WBGene00006819 |
unc-87 encodes, through alternative splicing, two proteins that are required to maintain the structure of myofilaments in body wall muscle cells; UNC-87 proteins resemble the C-terminal repeat region of calponin but have no obvious orthologs outside of nematodes; in vitro, UNC-87 proteins exist as monomers in solution, associate with thin (F-actin) filaments but not with monomeric G-actin, and bundle F-actin filaments; in vivo, UNC-87 proteins reside in the I-band of bodywall muscle, and GFP-tagged UNC-87 associates with actin stress fibers; unc-87 mutants show degeneration of myofilaments, are profoundly immobile, and have noticeable defects in egg-laying; the unc-87 mutant phenotype is partially suppressed by the unc-54(s95) mutation, which lowers myosin activity but leaves myofilaments intact, indicating that UNC-87 prevents damage by mechanical stress on myofilaments.
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Y51F10.7 | Y51F10.7 | WBGene00021768 | View | |
ZK1320.3 | ZK1320.3 | WBGene00014253 | View |