Module
- Number
- 43
- Regulatory Genes
- 7
- Module Genes
- 51
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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nhr-172 | C54F6.9 | WBGene00016927 | 354 | View | |
cey-2 | F46F11.2 | WBGene00000473 | 340 |
cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; CEY-2 associates with CGH-1 and CEY-3/4 in cytoplasmic particles of the gonad and early embryo; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known.
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hmg-11 | T05A7.4 | WBGene00001976 | 208 | View | |
K11H3.4 | K11H3.4 | WBGene00010781 | 184 | View | |
zim-1 | T07G12.6 | WBGene00011597 | 162 |
zim-1 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-2/-3, and C02F5.12; ZIM-1 specifically required for homolog pairing, synapsis, and segregation of chromosomes II and III during meiosis; zim-1(tm1813) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes II and III; ZIM-1 associates with the left ends of chromosomes II and III, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-1 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-1 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-1 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
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rga-4 | Y75B7AL.4 | WBGene00022286 | 148 |
rga-4 encodes a GTPase-activating protein (GAP); RNAi experiments predicted to target rga-4 and the related rga-3 gene result in early embryonic defects, specifically defects in cortical contractility, non-muscle myosin NMY-2 distribution, and the relative size of PAR protein domains; in vitro, RGA-4 positively regulates RHO-1 GTPase activity, consistent with genetic studies showing that the rga-3/4(RNAi) phenotype requires RHO-1 activity.
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nhr-15 | F33E11.1 | WBGene00003614 | 106 |
nhr-15 is predicted to encode a member of the nuclear hormone receptor family.
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CLR Predictions
56 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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acdh-12 | E04F6.5 | WBGene00017125 |
E04F6.5 is orthologous to the human gene ACYL-CoA DEHYDROGENASE, VERY LONG-CHAIN (OMIM:201475), which when mutated leads to VLCAD deficiency, an inborn error of mitochondrial beta-oxidation.
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acl-2 | T06E8.1 | WBGene00011543 |
T06E8.1 is orthologous to the human gene 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 2 (LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE, BETA) (AGPAT2; OMIM:603100), which when mutated leads to disease; T06E8.1 protein is predicted to be mitochondrial.
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aip-1 | F58E10.4 | WBGene00000097 |
aip-1 encodes an AN-1-like zinc finger-containing protein homologous to arsenite-inducible RNA-associated protein (AIRAP), conserved among C. elegans, Drosophila, and mammals; like AIRAP itself, AIP-1 protects cells from arsenite toxicity; AIP-1 is a predicted RNA binding protein that may function in ubiquitin-mediated proteolysis following aresenite treatment; AIP-1 does not appear to be essential for viability, but is expressed at high levels in hypodermal and intestinal cells following such treatment.
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ape-1 | F46F3.4 | WBGene00000146 |
ape-1 encodes an ortholog of inhibitory p53-interacting protein (iASPP); APE-1 binds CEP-1 in vitro, and shares 38% amino-acid identity in its ankyrin repeats and SH3 domain to iASPP, with many iASPP residues contacting p53 being conserved; RNAi of ape-1 induces CEP-1- and HUS-1-dependent apoptosis in the germline, consistent with inhibition of the CEP-1/HUS-1 DNA damage checkpoint by APE-1 in the germline; excess ape-1(RNAi) apoptosis also requires CED-3.
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bcs-1 | F54C9.6 | WBGene00010042 |
F54C9.6 encodes a protein orthologous to the human mitochondrial protein BCS1 (YEAST HOMOLOG)-LIKE (BCS1L; OMIM:603647); mutation of BCS1L leads to neonatal tubulopathy, encephalopathy, and liver failure, or to GRACILE syndrome.
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C01B10.8 | C01B10.8 | WBGene00015282 | View | |
C34D4.13 | C34D4.13 | WBGene00016404 | View | |
ceh-38 | F22D3.1 | WBGene00000459 |
ceh-38 encodes two proteins, by alternative splicing, that belong to the ONECUT class of homeodomain proteins (which includes mammalian hepatocyte nuclear factor-6); ceh-38 is expressed from embryos to adults, and in many different tissues (e.g., pharynx, gut, hypodermis and many nerve cells), but has no known function in vivo.
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ctns-1 | C41C4.7 | WBGene00008052 |
C41C4.7 encodes an ortholog of the human cystinosin gene (CTNS; OMIM:606272, which when mutated leads to nephropathic cystinosis (OMIM:219800); sequence analysis suggests that cystinosin is an integral lysosomal membrane protein.
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cyk-3 | ZK328.1 | WBGene00000874 |
cyk-3 encodes a functional ubiquitin C-terminal hydrolase required for embryonic viability and for cellular osmotic regulation; osmotic regulation defects in mutants contribute at least partially to cytokinesis defects in mutant embryos.
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cyld-1 | F40F12.5 | WBGene00009594 |
F40F12.5 encodes an ortholog of human CYLD1 (OMIM:605018, mutated in cylindromatosis); CYLD1 binds several members of the NF-kappaB signalling pathway, and can deubiquitinate target proteins.
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D2023.6 | D2023.6 | WBGene00008410 |
D2023.6 is orthologous to a set of uncharacterized putative protein kinases from eukaryotes and from prokaryotes (e.g., UbiB from E. coli), and paralogous to COQ-8 from C. elegans and ABC1 (COQ8) from S. cerevisiae; like COQ-8, D2023.6 may be involved in ubiquinone (coenzyme Q9) biosynthesis.
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E01B7.1 | E01B7.1 | WBGene00008441 | View | |
F01F1.2 | F01F1.2 | WBGene00017159 | View | |
F39H2.3 | F39H2.3 | WBGene00009563 | View | |
F48E8.6 | F48E8.6 | WBGene00018612 | View | |
F53C11.4 | F53C11.4 | WBGene00009974 | View | |
F53C11.5 | F53C11.5 | WBGene00009975 | View | |
F58G1.2 | F58G1.2 | WBGene00010264 | View | |
F58H1.3 | F58H1.3 | WBGene00010286 | View | |
gly-20 | C03E10.4 | WBGene00001645 |
gly-20 is orthologous to the human gene MANNOSYL (ALPHA-1,6-)-GLYCOPROTEIN BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE (MGAT2; OMIM:602616), which when mutated leads to carbohydrate-deficient glycoprotein syndrome, type II.
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haf-2 | F43E2.4 | WBGene00001812 |
haf-2 encodes a predicted transmembrane protein of the ATP-binding cassette (ABC) transporter superfamily; by homology, HAF-2 is proposed to function in ATP-dependent transport of molecules across plasma and intracellular membranes; however, as loss of HAF-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of HAF-2 in C. elegans development and/or behavior is not yet known.
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hgrs-1 | C07G1.5 | WBGene00004101 |
hgrs-1 encodes a VHS and FYVE zinc finger-domain containing protein that is the C. elegans ortholog of S. cerevisiae Vps27p and mammalian hepatocyte growth factor-regulated tyrosine kinase substrate (HGS); hgrs-1 activity is essential for molting and thus for proper larval development; consistent with its proposed role in the endocytic pathway, HGRS-1 is also required for proper trafficking of the LRP-1 low-density lipoprotein receptor-related protein 1 and for endosome maturation and regulation of autophagic vesicle accumulation; an HGRS-1::GFP fusion protein is widely expressed, but particularly enriched in epithelial cells; within cells, HGRS-1::GFP localizes to endosomal membranes.
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K01D12.6 | K01D12.6 | WBGene00010465 | View | |
K09E4.3 | K09E4.3 | WBGene00010721 | View | |
M01G5.3 | M01G5.3 | WBGene00019716 | View | |
mmaa-1 | T02G5.13 | WBGene00020169 | View | |
mtm-6 | F53A2.8 | WBGene00003478 |
mtm-6 encodes a myotubularin orthologous to human MTMR6 (OMIM:603561), MTMR7 (OMIM:603562), and MTMR8, that regulates phosphoinositide 3-phosphate levels in vivo and whose mutation blocks endocytosis by coelomocytes; the MTM-6A isoform, which rescues the endocytic defect of mtm-6 mutants, is believed to function as part of a complex with MTM-9 and MTM-6A is predominantly localized to the coelomocyte cytoplasm, with some localization to the coelomocyte membrane.
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prx-19 | F54F2.8 | WBGene00004201 |
prx-19 is orthologous to the human gene PEROXISOMAL FARNESYLATED PROTEIN (PXF; OMIM:600279), which when mutated leads to peroxisome biogenesis (Zellweger) syndrome of complementation group J.
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R06C1.2 | R06C1.2 | WBGene00011058 | View | |
R53.7 | R53.7 | WBGene00011276 | View | |
rab-21 | T01B7.3 | WBGene00004279 |
rab-21 encodes a Rab GTPase most closely related to the Drosophila and vertebrate Rab21 GTPases and Saccharomyces cerevisiae VPS21; by homology, RAB-21 is predicted to be involved in membrane trafficking/vesicle transport; loss of rab-21 activity via RNAi results in 7-8% embryonic lethality.
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rab-6.1 | F59B2.7 | WBGene00004269 |
rab-6.1 encodes a small, monomeric Rab GTPase that is most closely related to the Drosophila and mammalian Rab6 GTPases; by homology, RAB-6.1 is predicted to function in the regulation of intracellular membrane trafficking; RNAi experiments indicate that rab-6.1 is required redundantly with rab-6.2 for normal embryonic development and reproduction.
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raga-1 | T24F1.1 | WBGene00006414 | View | |
rskn-1 | T01H8.1 | WBGene00011352 | View | |
spe-39 | ZC404.3 | WBGene00004975 | View | |
T05H10.1 | T05H10.1 | WBGene00011507 | View | |
T07F12.2 | T07F12.2 | WBGene00020322 | View | |
T12A2.8 | T12A2.8 | WBGene00020442 | View | |
T12B3.4 | T12B3.4 | WBGene00020447 | View | |
T20D3.5 | T20D3.5 | WBGene00011858 | View | |
tag-321 | C33H5.19 | WBGene00044325 | View | |
tag-322 | C33H5.10 | WBGene00044326 | View | |
W09D10.1 | W09D10.1 | WBGene00012359 | View | |
Y39B6A.3 | Y39B6A.3 | WBGene00012666 | View | |
Y55F3AM.9 | Y55F3AM.9 | WBGene00021926 | View | |
Y73B6BL.4 | Y73B6BL.4 | WBGene00022233 | View | |
ZK1248.15 | ZK1248.15 | WBGene00022883 | View | |
ZK177.8 | ZK177.8 | WBGene00022673 | View | |
ZK353.9 | ZK353.9 | WBGene00022704 | View | |
ZK546.2 | ZK546.2 | WBGene00022759 | View |